Roles of microRNAs in atherosclerosis and restenosis
<p>Abstract</p> <p>Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly performed in patients with atherosclerotic disease. H...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | Journal of Biomedical Science |
| Online Access: | http://www.jbiomedsci.com/content/19/1/79 |
| _version_ | 1811252323526115328 |
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| author | Chen Li-Jing Lim Seh Yeh Yi-Ting Lien Sheng-Chieh Chiu Jeng-Jiann |
| author_facet | Chen Li-Jing Lim Seh Yeh Yi-Ting Lien Sheng-Chieh Chiu Jeng-Jiann |
| author_sort | Chen Li-Jing |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly performed in patients with atherosclerotic disease. However, the restenosis usually has a high incidence rate in angioplasty patients. Although the pathophysiological mechanisms underlying atherosclerosis and restenosis have been well established, new signaling molecules that control the progress of these pathologies have continuously been discovered. MicroRNAs (miRs) have recently emerged as a novel class of gene regulators that work via transcriptional degradation and translational inhibition or activation. Over 30% of genes in the cell can be directly regulated by miRs. Thus, miRs are recognized as crucial regulators in normal development, physiology and pathogenesis. AIterations of miR expression profiles have been revealed in diverse vascular diseases. A variety of functions of vascular cells, such as cell differentiation, contraction, migration, proliferation and inflammation that are involved in angiogenesis, neointimal formation and lipid metabolism underlying various vascular diseases, have been found to be regulated by miRs. This review summarizes current research progress and knowledge on the roles of miRs in regulating vascular cell function in atherosclerosis and restenosis. These discoveries are expected to present opportunities for clinical diagnostic and therapeutic approaches in vascular diseases resulting from atherosclerosis and restenosis.</p> |
| first_indexed | 2024-04-12T16:32:59Z |
| format | Article |
| id | doaj.art-86bc452e050b4dc2bbeaa720a9c6f268 |
| institution | Directory Open Access Journal |
| issn | 1021-7770 1423-0127 |
| language | English |
| last_indexed | 2024-04-12T16:32:59Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-86bc452e050b4dc2bbeaa720a9c6f2682022-12-22T03:25:05ZengBMCJournal of Biomedical Science1021-77701423-01272012-08-011917910.1186/1423-0127-19-79Roles of microRNAs in atherosclerosis and restenosisChen Li-JingLim SehYeh Yi-TingLien Sheng-ChiehChiu Jeng-Jiann<p>Abstract</p> <p>Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly performed in patients with atherosclerotic disease. However, the restenosis usually has a high incidence rate in angioplasty patients. Although the pathophysiological mechanisms underlying atherosclerosis and restenosis have been well established, new signaling molecules that control the progress of these pathologies have continuously been discovered. MicroRNAs (miRs) have recently emerged as a novel class of gene regulators that work via transcriptional degradation and translational inhibition or activation. Over 30% of genes in the cell can be directly regulated by miRs. Thus, miRs are recognized as crucial regulators in normal development, physiology and pathogenesis. AIterations of miR expression profiles have been revealed in diverse vascular diseases. A variety of functions of vascular cells, such as cell differentiation, contraction, migration, proliferation and inflammation that are involved in angiogenesis, neointimal formation and lipid metabolism underlying various vascular diseases, have been found to be regulated by miRs. This review summarizes current research progress and knowledge on the roles of miRs in regulating vascular cell function in atherosclerosis and restenosis. These discoveries are expected to present opportunities for clinical diagnostic and therapeutic approaches in vascular diseases resulting from atherosclerosis and restenosis.</p>http://www.jbiomedsci.com/content/19/1/79 |
| spellingShingle | Chen Li-Jing Lim Seh Yeh Yi-Ting Lien Sheng-Chieh Chiu Jeng-Jiann Roles of microRNAs in atherosclerosis and restenosis Journal of Biomedical Science |
| title | Roles of microRNAs in atherosclerosis and restenosis |
| title_full | Roles of microRNAs in atherosclerosis and restenosis |
| title_fullStr | Roles of microRNAs in atherosclerosis and restenosis |
| title_full_unstemmed | Roles of microRNAs in atherosclerosis and restenosis |
| title_short | Roles of microRNAs in atherosclerosis and restenosis |
| title_sort | roles of micrornas in atherosclerosis and restenosis |
| url | http://www.jbiomedsci.com/content/19/1/79 |
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