Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications
Circular RNAs (circRNAs) are class of non-coding RNA, which are characterized by a covalently closed loop structure. Functionally they can act on cellular physiology, notably by sponging microRNAs (miR), regulating gene expression or interacting with binding protein. To date, circRNAs might represen...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1035159/full |
| _version_ | 1797984559569043456 |
|---|---|
| author | Melissa Yepmo Jean-Baptiste Potier Jean-Baptiste Potier Michel Pinget Anastasia Grabarz Karim Bouzakri Karim Bouzakri Aurore Dumond Bourie |
| author_facet | Melissa Yepmo Jean-Baptiste Potier Jean-Baptiste Potier Michel Pinget Anastasia Grabarz Karim Bouzakri Karim Bouzakri Aurore Dumond Bourie |
| author_sort | Melissa Yepmo |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are class of non-coding RNA, which are characterized by a covalently closed loop structure. Functionally they can act on cellular physiology, notably by sponging microRNAs (miR), regulating gene expression or interacting with binding protein. To date, circRNAs might represent an interesting, underexploited avenue for new target discovery for therapeutic applications, especially in the liver. The first characteristic of non-alcoholic fatty liver disease (NAFLD) is hepatic cholesterol accumulation, followed by its advanced form of the affection, nonalcoholic steatohepatitis (NASH), due to the occurrence of lobular inflammation, irreversible fibrosis, and in some cases hepatocellular carcinoma (HCC). Therefore, studies have investigated the importance of the dysregulation of circRNAs in the onset of metabolic disorders. In this review, we summarize the potential role of circRNAs in the development of metabolic diseases associated with the liver such as NAFLD or NASH, and their potential to become therapeutic strategies for these pathologies. |
| first_indexed | 2024-04-11T07:03:34Z |
| format | Article |
| id | doaj.art-86bc648213ab49b3aa6de5bd3a304987 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T07:03:34Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-86bc648213ab49b3aa6de5bd3a3049872022-12-22T04:38:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10351591035159Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complicationsMelissa Yepmo0Jean-Baptiste Potier1Jean-Baptiste Potier2Michel Pinget3Anastasia Grabarz4Karim Bouzakri5Karim Bouzakri6Aurore Dumond Bourie7Centre européen d’étude du Diabète, Unité Mixte de Recherche de l’Université de Strasbourg « Diabète et Thérapeutique », Strasbourg, FranceCentre européen d’étude du Diabète, Unité Mixte de Recherche de l’Université de Strasbourg « Diabète et Thérapeutique », Strasbourg, FranceILONOV, Strasbourg, FranceCentre européen d’étude du Diabète, Unité Mixte de Recherche de l’Université de Strasbourg « Diabète et Thérapeutique », Strasbourg, FranceILONOV, Strasbourg, FranceCentre européen d’étude du Diabète, Unité Mixte de Recherche de l’Université de Strasbourg « Diabète et Thérapeutique », Strasbourg, FranceILONOV, Strasbourg, FranceCentre européen d’étude du Diabète, Unité Mixte de Recherche de l’Université de Strasbourg « Diabète et Thérapeutique », Strasbourg, FranceCircular RNAs (circRNAs) are class of non-coding RNA, which are characterized by a covalently closed loop structure. Functionally they can act on cellular physiology, notably by sponging microRNAs (miR), regulating gene expression or interacting with binding protein. To date, circRNAs might represent an interesting, underexploited avenue for new target discovery for therapeutic applications, especially in the liver. The first characteristic of non-alcoholic fatty liver disease (NAFLD) is hepatic cholesterol accumulation, followed by its advanced form of the affection, nonalcoholic steatohepatitis (NASH), due to the occurrence of lobular inflammation, irreversible fibrosis, and in some cases hepatocellular carcinoma (HCC). Therefore, studies have investigated the importance of the dysregulation of circRNAs in the onset of metabolic disorders. In this review, we summarize the potential role of circRNAs in the development of metabolic diseases associated with the liver such as NAFLD or NASH, and their potential to become therapeutic strategies for these pathologies.https://www.frontiersin.org/articles/10.3389/fendo.2022.1035159/fullNASHNAFLDcircRNAlivercrosstalkhepatocellular carcinoma |
| spellingShingle | Melissa Yepmo Jean-Baptiste Potier Jean-Baptiste Potier Michel Pinget Anastasia Grabarz Karim Bouzakri Karim Bouzakri Aurore Dumond Bourie Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications Frontiers in Endocrinology NASH NAFLD circRNA liver crosstalk hepatocellular carcinoma |
| title | Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications |
| title_full | Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications |
| title_fullStr | Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications |
| title_full_unstemmed | Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications |
| title_short | Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications |
| title_sort | discussing the role of circular rna in the pathogenesis of non alcoholic fatty liver disease and its complications |
| topic | NASH NAFLD circRNA liver crosstalk hepatocellular carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1035159/full |
| work_keys_str_mv | AT melissayepmo discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT jeanbaptistepotier discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT jeanbaptistepotier discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT michelpinget discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT anastasiagrabarz discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT karimbouzakri discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT karimbouzakri discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications AT auroredumondbourie discussingtheroleofcircularrnainthepathogenesisofnonalcoholicfattyliverdiseaseanditscomplications |