Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties
Cancer stem cells (CSCs) are a subpopulation of cancer cells possessing stemness characteristics that are closely associated with tumor proliferation, recurrence and resistance to therapy. Recent studies have shown that different cytoskeletal components and remodeling processes have a profound impac...
| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artikel |
| Språk: | English |
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MDPI AG
2022-11-01
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| Serie: | Pharmaceuticals |
| Ämnen: | |
| Länkar: | https://www.mdpi.com/1424-8247/15/11/1369 |
| _version_ | 1827645791047516160 |
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| author | Yuqiang Li Dan Wang Heming Ge Cenap Güngör Xuejun Gong Yongheng Chen |
| author_facet | Yuqiang Li Dan Wang Heming Ge Cenap Güngör Xuejun Gong Yongheng Chen |
| author_sort | Yuqiang Li |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) are a subpopulation of cancer cells possessing stemness characteristics that are closely associated with tumor proliferation, recurrence and resistance to therapy. Recent studies have shown that different cytoskeletal components and remodeling processes have a profound impact on the behavior of CSCs. In this review, we outline the different cytoskeletal components regulating the properties of CSCs and discuss current and ongoing therapeutic strategies targeting the cytoskeleton. Given the many challenges currently faced in targeted cancer therapy, a deeper comprehension of the molecular events involved in the interaction of the cytoskeleton and CSCs will help us identify more effective therapeutic strategies to eliminate CSCs and ultimately improve patient survival. |
| first_indexed | 2024-03-09T18:45:08Z |
| format | Article |
| id | doaj.art-86bcc1ab1b0a4eeeba23c8dc7d8d2054 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T18:45:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-86bcc1ab1b0a4eeeba23c8dc7d8d20542023-11-24T06:18:50ZengMDPI AGPharmaceuticals1424-82472022-11-011511136910.3390/ph15111369Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell PropertiesYuqiang Li0Dan Wang1Heming Ge2Cenap Güngör3Xuejun Gong4Yongheng Chen5Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of General Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, ChinaCancer stem cells (CSCs) are a subpopulation of cancer cells possessing stemness characteristics that are closely associated with tumor proliferation, recurrence and resistance to therapy. Recent studies have shown that different cytoskeletal components and remodeling processes have a profound impact on the behavior of CSCs. In this review, we outline the different cytoskeletal components regulating the properties of CSCs and discuss current and ongoing therapeutic strategies targeting the cytoskeleton. Given the many challenges currently faced in targeted cancer therapy, a deeper comprehension of the molecular events involved in the interaction of the cytoskeleton and CSCs will help us identify more effective therapeutic strategies to eliminate CSCs and ultimately improve patient survival.https://www.mdpi.com/1424-8247/15/11/1369cytoskeletalcytoskeleton-associated proteinscancer stem cellsrecurrencemetastasisdrug resistance |
| spellingShingle | Yuqiang Li Dan Wang Heming Ge Cenap Güngör Xuejun Gong Yongheng Chen Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties Pharmaceuticals cytoskeletal cytoskeleton-associated proteins cancer stem cells recurrence metastasis drug resistance |
| title | Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties |
| title_full | Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties |
| title_fullStr | Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties |
| title_full_unstemmed | Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties |
| title_short | Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties |
| title_sort | cytoskeletal and cytoskeleton associated proteins key regulators of cancer stem cell properties |
| topic | cytoskeletal cytoskeleton-associated proteins cancer stem cells recurrence metastasis drug resistance |
| url | https://www.mdpi.com/1424-8247/15/11/1369 |
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