Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

ABSTRACT Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health. These recombinants may initially have substantial replication...

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Bibliographic Details
Main Authors: Jonathan M. O. Rawson, Olga A. Nikolaitchik, Jennifer A. Yoo, Xayathed Somoulay, Matthew A. Brown, Franck S. Mbuntcha Bogni, Vinay K. Pathak, Ferri Soheilian, Ryan L. Slack, Stefan G. Sarafianos, Wei-Shau Hu
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
Gag
HIV-1
HIV-2
RNA packaging
adaptation
chimeric virus
Online Access:https://journals.asm.org/doi/10.1128/mbio.02220-22

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