From glucose sensing to exocytosis: takes from maturity onset diabetes of the young

From glucose sensing to exocytosis: takes from maturity onset diabetes of the young

Monogenic diabetes gave us simplified models of complex molecular processes occurring within β-cells, which allowed to explore the roles of numerous proteins from single protein perspective. Constellation of characteristic phenotypic features and wide application of genetic sequencing techniques to...

Full description

Bibliographic Details
Main Authors:	Sama Samadli, Qiaoli Zhou, Bixia Zheng, Wei Gu, Aihua Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Endocrinology
Subjects:	MODY maturity onset diabetes of the young glucokinase channelopathy unfolded protein response transcription factors
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1188301/full

Similar Items

Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients
by: Jaeyong Cho, et al.
Published: (2023-10-01)

Maturity-Onset Diabetes of the Young: Mutations, Physiological Consequences, and Treatment Options
by: Hazar Younis, et al.
Published: (2022-10-01)

Molecular docking assessment of pyridone derivatives as glucokinase activators
by: Y. Nanda Kumar, et al.
Published: (2012-10-01)

Molecular genetic analysis and clinical consideration of two families with GCK gene mutation
by: WANG Zhi-xin, ZUO Qing-yao, LI Wei, CHEN Jia, DENG Wei
Published: (2020-12-01)

A case of maturity-onset diabetes of the young type 4 in Korea
by: Geu-Meum Park, et al.
Published: (2022-05-01)

A rare splice site mutation in the gene encoding glucokinase/hexokinase 4 in a patient with MODY type 2
by: D. E. Ivanoshchuk, et al.
Published: (2020-05-01)

Screening and functional analysis of mutations in NEUROD1 gene in pedigrees of maturity-onset diabetes of the young
by: ZHANG Juan, et al.
Published: (2023-10-01)

UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
by: Jaeyong Cho, et al.
Published: (2022-08-01)

Insights into the Genetics and Signaling Pathways in Maturity-Onset Diabetes of the Young
by: Madalena Sousa, et al.
Published: (2022-10-01)

Distinguishing the lipid profile of GCK-MODY patients and its correlation with hsCRP levels
by: Fan Ping, et al.
Published: (2022-10-01)

The Mutation Spectrum of Maturity Onset Diabetes of the Young (MODY)-Associated Genes among Western Siberia Patients
by: Dinara E. Ivanoshchuk, et al.
Published: (2021-01-01)

Prevalence and clinical profile of maturity onset diabetes of the young among people with diabetes attending a tertiary care centre
by: Javaid Ahmad Bhat, et al.
Published: (2022-01-01)

Maturity-Onset Diabetes of the Young (MODY): Genetic Causes, Clinical Characteristics, Considerations for Testing, and Treatment Options
by: Zoltan Antal
Published: (2021-12-01)

Targeted gene panel analysis of Japanese patients with maturity‐onset diabetes of the young‐like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes
by: Tohru Yorifuji, et al.
Published: (2023-03-01)

“Pesto” Mutation: Phenotypic and Genotypic Characteristics of Eight GCK/MODY Ligurian Patients
by: Alessandro Salina, et al.
Published: (2023-02-01)

Monogenic diabetes associated with PAX4 gene mutations (MODY9): first description in Russia
by: Natalya A. Zubkova, et al.
Published: (2017-12-01)

Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives
by: Parveena Firdous, et al.
Published: (2018-05-01)

The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study
by: Asma A. Elashi, et al.
Published: (2022-12-01)

Maturity-onset diabetes of the young secondary to HNF1B variants (HNF1B-MODY): a series of 10 patients from a single diabetes center
by: Sara Amaral, et al.
Published: (2023-02-01)

Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD
by: Ziqi Zhang, et al.
Published: (2023-08-01)

Statistical evidence for high‐penetrance MODY‐causing genes in a large population‐based cohort
by: Liana K. Billings, et al.
Published: (2022-11-01)

Glucokinase Inactivation Ameliorates Lipid Accumulation and Exerts Favorable Effects on Lipid Metabolism in Hepatocytes
by: Ziyan Xie, et al.
Published: (2023-02-01)

GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY
by: Tongtong Dai, et al.
Published: (2023-04-01)

Diagnosis and Treatment of MODY: An Updated Mini Review
by: Abegail Tshivhase, et al.
Published: (2021-10-01)

MODY2 diagnostic issues in adults
by: Irina V. Kononenko, et al.
Published: (2019-10-01)

Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment
by: Anne Cathrine Baun Thuesen, et al.
Published: (2023-06-01)

Maturity-Onset Diabetes of the Young Identified Among Algerian Probands with Early-Onset Diabetes
by: Bouldjennet F, et al.
Published: (2020-12-01)

HYPOKALEMIC PERIODIC PARALYSIS: AGE OF ONSET IN A RETROSPECTIVE STUDY
by: M. H. Harirchian, et al.
Published: (2003-08-01)

Analysis of APPL1 Gene Polymorphisms in Patients with a Phenotype of Maturity Onset Diabetes of the Young
by: Dinara E. Ivanoshchuk, et al.
Published: (2020-08-01)

A Novel De Novo Missense Mutation in HNF4A Resulting in Sulfonylurea-Responsive Maturity-onset Diabetes of the Young
by: Sezer Acar, et al.
Published: (2018-09-01)

Identification and precision therapy for three maturity-onset diabetes of the young (MODY) families caused by mutations in the HNF4A gene
by: Juan Zhang, et al.
Published: (2023-08-01)

Genetic testing for misclassified monogenic diabetes in Māori and Pacific peoples in Aōtearoa New Zealand with early-onset type 2 diabetes
by: Zanetta Toomata, et al.
Published: (2023-05-01)

Variants of the HNF4A and HNF1A genes in patients with impaired glucose metabolism and dyslipidemia
by: Dinara E. Ivanoshchuk, et al.
Published: (2022-01-01)

Purtscher-like retinopathy in a 19-year-old with maturity-onset diabetes of the young: a case report
by: Angela J. Oh, et al.
Published: (2023-06-01)

A Novel <i>GCK</i> Large Genomic Rearrangement in a Patient with MODY-2 Detected by Clinical Exome Sequencing
by: Paola Concolino, et al.
Published: (2022-11-01)

The Effect of Interval Training on GCK Expression in Hepatocytes and Glucose Homeostasis in Type 2 Diabetes Rats
by: Fatemeh Nikseresht, et al.
Published: (2022-05-01)

POLYMORPHISM IN GENES INVOLVED IN LIPID METABOLISM IN MODY PATIENTS
by: M. I. Voevoda, et al.
Published: (2016-12-01)

Molecular docking, 2D-QSAR and ADMET studies of 4-sulfonyl-2-pyridone heterocycle as a potential glucokinase activator
by: Prateek Sharma, et al.
Published: (2023-12-01)

Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis
by: Ke Wang, et al.
Published: (2022-09-01)

Functional Inactivation of <i>Drosophila</i> <i>GCK</i> Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2
by: Elisa Mascolo, et al.
Published: (2021-01-01)