IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge.
Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based VEE vaccine candidate based up the IE serotype that offers complete protection against a lethal sub...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-05-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4447396?pdf=render |
| _version_ | 1819171053225639936 |
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| author | Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy |
| author_facet | Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy |
| author_sort | Shannan L Rossi |
| collection | DOAJ |
| description | Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based VEE vaccine candidate based up the IE serotype that offers complete protection against a lethal subtype IE VEEV challenge in mice. Here we demonstrate the IRES-based vaccine's ability to protect against febrile disease in cynomolgus macaques. Vaccination was well tolerated and elicited robust neutralizing antibody titers noticed as early as day 14. Moreover, complete protection from disease characterized by absence of viremia and characteristic fever following aerosolized IE VEEV challenge was observed in all vaccinees compared to control animals, which developed clinical disease. Together, these results highlight the safety and efficacy of IRES-based VEEV vaccine to protect against an endemic, pathogenic VEEV IE serotype. |
| first_indexed | 2024-12-22T19:45:10Z |
| format | Article |
| id | doaj.art-86bf66e5246e4f38be60df686be47c59 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-22T19:45:10Z |
| publishDate | 2015-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-86bf66e5246e4f38be60df686be47c592022-12-21T18:14:43ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352015-05-0195e000379710.1371/journal.pntd.0003797IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge.Shannan L RossiKasi E Russell-LodrigueStephanie Z KilleenEryu WangGrace LealNicholas A BergrenHeather Vinet-OliphantScott C WeaverChad J RoyVenezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based VEE vaccine candidate based up the IE serotype that offers complete protection against a lethal subtype IE VEEV challenge in mice. Here we demonstrate the IRES-based vaccine's ability to protect against febrile disease in cynomolgus macaques. Vaccination was well tolerated and elicited robust neutralizing antibody titers noticed as early as day 14. Moreover, complete protection from disease characterized by absence of viremia and characteristic fever following aerosolized IE VEEV challenge was observed in all vaccinees compared to control animals, which developed clinical disease. Together, these results highlight the safety and efficacy of IRES-based VEEV vaccine to protect against an endemic, pathogenic VEEV IE serotype.http://europepmc.org/articles/PMC4447396?pdf=render |
| spellingShingle | Shannan L Rossi Kasi E Russell-Lodrigue Stephanie Z Killeen Eryu Wang Grace Leal Nicholas A Bergren Heather Vinet-Oliphant Scott C Weaver Chad J Roy IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. PLoS Neglected Tropical Diseases |
| title | IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
| title_full | IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
| title_fullStr | IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
| title_full_unstemmed | IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
| title_short | IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. |
| title_sort | ires containing veev vaccine protects cynomolgus macaques from ie venezuelan equine encephalitis virus aerosol challenge |
| url | http://europepmc.org/articles/PMC4447396?pdf=render |
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