MIF contribution to progressive brain diseases
Abstract Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-023-02993-6 |
| _version_ | 1797363061273657344 |
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| author | Agata Matejuk Gil Benedek Richard Bucala Szymon Matejuk Halina Offner Arthur A. Vandenbark |
| author_facet | Agata Matejuk Gil Benedek Richard Bucala Szymon Matejuk Halina Offner Arthur A. Vandenbark |
| author_sort | Agata Matejuk |
| collection | DOAJ |
| description | Abstract Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a process of unresolved, chronic inflammation. Macrophage migration inhibitory factor, MIF, is an inflammatory mediator that recently gained interest of neuro-researchers due to its varied effects on the CNS such as participation of nervous system development, neuroendocrine functions, and modulation of neuroinflammation. MIF appears to be a candidate as a new biomarker and target of novel therapeutics against numerous neurologic diseases ranging from cancer, autoimmune diseases, vascular diseases, neurodegenerative pathology to psychiatric disorders. In this review, we will focus on MIF’s crucial role in neurological diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD) and glioblastoma (GBM). |
| first_indexed | 2024-03-08T16:15:22Z |
| format | Article |
| id | doaj.art-86c0a6f346054bb8830fc268db3fc706 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-03-08T16:15:22Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-86c0a6f346054bb8830fc268db3fc7062024-01-07T12:37:13ZengBMCJournal of Neuroinflammation1742-20942024-01-0121111610.1186/s12974-023-02993-6MIF contribution to progressive brain diseasesAgata Matejuk0Gil Benedek1Richard Bucala2Szymon Matejuk3Halina Offner4Arthur A. Vandenbark5Department of Immunology, Collegium Medicum, University of Zielona GóraTissue Typing and Immunogenetics Unit, Department of Genetics, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of JerusalemDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale University School of MedicineJagiellonian UniversityNeuroimmunology Research, R&D-31, VA Portland Health Care SystemNeuroimmunology Research, R&D-31, VA Portland Health Care SystemAbstract Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a process of unresolved, chronic inflammation. Macrophage migration inhibitory factor, MIF, is an inflammatory mediator that recently gained interest of neuro-researchers due to its varied effects on the CNS such as participation of nervous system development, neuroendocrine functions, and modulation of neuroinflammation. MIF appears to be a candidate as a new biomarker and target of novel therapeutics against numerous neurologic diseases ranging from cancer, autoimmune diseases, vascular diseases, neurodegenerative pathology to psychiatric disorders. In this review, we will focus on MIF’s crucial role in neurological diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD) and glioblastoma (GBM).https://doi.org/10.1186/s12974-023-02993-6MIFNeuroinflammationNeurodegenerationMSADAstrocytoma |
| spellingShingle | Agata Matejuk Gil Benedek Richard Bucala Szymon Matejuk Halina Offner Arthur A. Vandenbark MIF contribution to progressive brain diseases Journal of Neuroinflammation MIF Neuroinflammation Neurodegeneration MS AD Astrocytoma |
| title | MIF contribution to progressive brain diseases |
| title_full | MIF contribution to progressive brain diseases |
| title_fullStr | MIF contribution to progressive brain diseases |
| title_full_unstemmed | MIF contribution to progressive brain diseases |
| title_short | MIF contribution to progressive brain diseases |
| title_sort | mif contribution to progressive brain diseases |
| topic | MIF Neuroinflammation Neurodegeneration MS AD Astrocytoma |
| url | https://doi.org/10.1186/s12974-023-02993-6 |
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