Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature

Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are thought to develop from pluripotent uterine mesenchymal cells or endometrial stromal cells with secondary sex-cord differentiation. The patient was a 73-year-old postmenopausal woman who had abnormal vaginal bleeding, and she underwent...

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Main Authors: Martina Ferrara, Basilio Pecorino, Maria Gabriella D’Agate, Giuseppe Angelico, Ettore Domenico Capoluongo, Umberto Malapelle, Francesco Pepe, Paolo Scollo, Liliana Mereu
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/12/22/7131
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author Martina Ferrara
Basilio Pecorino
Maria Gabriella D’Agate
Giuseppe Angelico
Ettore Domenico Capoluongo
Umberto Malapelle
Francesco Pepe
Paolo Scollo
Liliana Mereu
author_facet Martina Ferrara
Basilio Pecorino
Maria Gabriella D’Agate
Giuseppe Angelico
Ettore Domenico Capoluongo
Umberto Malapelle
Francesco Pepe
Paolo Scollo
Liliana Mereu
author_sort Martina Ferrara
collection DOAJ
description Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are thought to develop from pluripotent uterine mesenchymal cells or endometrial stromal cells with secondary sex-cord differentiation. The patient was a 73-year-old postmenopausal woman who had abnormal vaginal bleeding, and she underwent a laparoscopic hysterectomy with bilateral salpingo-oophorectomy. The diagnosis was a case of UTROSCT. A scoping review of the UTROSCT case report present in the literature has been conducted, and 63 articles were found, of which 45 were considered for the 66 clinical cases examined. At the time of diagnosis, six metastatic localizations were found in 59 patients undergoing demolitive surgery (10.2%). Recurrences were diagnosed in 13/59 (22%) patients with multiple locations. A molecular study was performed in 18/66 cases (27.3%) and genetic alterations were found in 10/18 (55.6%) patients. UTROSCTs are considered rare uterine tumors, typically with a favorable prognosis, and are generally considered to have a good prognosis. But, from the review done, they may already manifest themselves at advanced stages, with the possibility of recurrences even at a distance. It would, therefore, be important to be able to define the most aggressive forms and, perhaps, molecular investigation with sequencing could help identify patients most at risk.
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spelling doaj.art-86c3834f52994c9d8402e5fb4579d7132023-11-24T14:49:36ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011222713110.3390/jcm12227131Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the LiteratureMartina Ferrara0Basilio Pecorino1Maria Gabriella D’Agate2Giuseppe Angelico3Ettore Domenico Capoluongo4Umberto Malapelle5Francesco Pepe6Paolo Scollo7Liliana Mereu8Department of Obstetrics and Gynecology, Cannizzaro Hospital, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Obstetrics and Gynecology, Cannizzaro Hospital, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Obstetrics and Gynecology, Cannizzaro Hospital, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Anatomic Pathology and Histology, Cannizzaro Hospital, 95100 Catania, ItalyDepartment of Clinical Pathology and Genomics, Cannizzaro Hospital, 95100 Catania, ItalyDepartment of Public Health, University of Naples Federico II, 80126 Naples, ItalyDepartment of Public Health, University of Naples Federico II, 80126 Naples, ItalyDepartment of Obstetrics and Gynecology, Cannizzaro Hospital, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Obstetrics and Gynecology, Policlinico G Rodolico, CHIRMED, University of Catania, 95124 Catania, ItalyUterine tumors resembling ovarian sex-cord tumors (UTROSCT) are thought to develop from pluripotent uterine mesenchymal cells or endometrial stromal cells with secondary sex-cord differentiation. The patient was a 73-year-old postmenopausal woman who had abnormal vaginal bleeding, and she underwent a laparoscopic hysterectomy with bilateral salpingo-oophorectomy. The diagnosis was a case of UTROSCT. A scoping review of the UTROSCT case report present in the literature has been conducted, and 63 articles were found, of which 45 were considered for the 66 clinical cases examined. At the time of diagnosis, six metastatic localizations were found in 59 patients undergoing demolitive surgery (10.2%). Recurrences were diagnosed in 13/59 (22%) patients with multiple locations. A molecular study was performed in 18/66 cases (27.3%) and genetic alterations were found in 10/18 (55.6%) patients. UTROSCTs are considered rare uterine tumors, typically with a favorable prognosis, and are generally considered to have a good prognosis. But, from the review done, they may already manifest themselves at advanced stages, with the possibility of recurrences even at a distance. It would, therefore, be important to be able to define the most aggressive forms and, perhaps, molecular investigation with sequencing could help identify patients most at risk.https://www.mdpi.com/2077-0383/12/22/7131uterine tumor resembling ovarian sex cord tumor (UTROSCT)review
spellingShingle Martina Ferrara
Basilio Pecorino
Maria Gabriella D’Agate
Giuseppe Angelico
Ettore Domenico Capoluongo
Umberto Malapelle
Francesco Pepe
Paolo Scollo
Liliana Mereu
Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
Journal of Clinical Medicine
uterine tumor resembling ovarian sex cord tumor (UTROSCT)
review
title Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
title_full Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
title_fullStr Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
title_full_unstemmed Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
title_short Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
title_sort uterine tumours resembling ovarian sex cord tumors a case report and review of the literature
topic uterine tumor resembling ovarian sex cord tumor (UTROSCT)
review
url https://www.mdpi.com/2077-0383/12/22/7131
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