Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles
Abstract Gold nanoparticles (GNPs) have shown considerable potential in a vast number of biomedical applications. However, currently there are no clinically approved injectable GNP formulations. Conversely, gold salts have been used in the clinic for nearly a century. Further, there is evidence of G...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202105957 |
| _version_ | 1818521550212562944 |
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| author | Aaron S. Schwartz‐Duval Konstantin V. Sokolov |
| author_facet | Aaron S. Schwartz‐Duval Konstantin V. Sokolov |
| author_sort | Aaron S. Schwartz‐Duval |
| collection | DOAJ |
| description | Abstract Gold nanoparticles (GNPs) have shown considerable potential in a vast number of biomedical applications. However, currently there are no clinically approved injectable GNP formulations. Conversely, gold salts have been used in the clinic for nearly a century. Further, there is evidence of GNP formation in patients treated with gold salts (i.e., chrysiasis). Recent reports evaluating this phenomenon in human cells and in murine models indicate that the use of gold ions for in situ formation of theranostic GNPs could greatly improve the delivery within dense biological tissues, increase efficiency of intracellular gold uptake, and specificity of GNP formation within cancer cells. These attributes in combination with safe clinical application of gold salts make this process a viable strategy for clinical translation. Here, the first summary of the current knowledge related to GNP biomineralization in mammalian cells is provided along with critical assessment of potential biomedical applications of this newly emergent field. |
| first_indexed | 2024-12-11T01:52:33Z |
| format | Article |
| id | doaj.art-86c47f676acf4246a37a9846e1f1c329 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-11T01:52:33Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-86c47f676acf4246a37a9846e1f1c3292022-12-22T01:24:42ZengWileyAdvanced Science2198-38442022-07-01920n/an/a10.1002/advs.202105957Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold NanoparticlesAaron S. Schwartz‐Duval0Konstantin V. Sokolov1Department of Imaging Physics The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USADepartment of Imaging Physics The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USAAbstract Gold nanoparticles (GNPs) have shown considerable potential in a vast number of biomedical applications. However, currently there are no clinically approved injectable GNP formulations. Conversely, gold salts have been used in the clinic for nearly a century. Further, there is evidence of GNP formation in patients treated with gold salts (i.e., chrysiasis). Recent reports evaluating this phenomenon in human cells and in murine models indicate that the use of gold ions for in situ formation of theranostic GNPs could greatly improve the delivery within dense biological tissues, increase efficiency of intracellular gold uptake, and specificity of GNP formation within cancer cells. These attributes in combination with safe clinical application of gold salts make this process a viable strategy for clinical translation. Here, the first summary of the current knowledge related to GNP biomineralization in mammalian cells is provided along with critical assessment of potential biomedical applications of this newly emergent field.https://doi.org/10.1002/advs.202105957bioimagingbiomineralizationgold nanoparticlesin situ therapytheragnostic |
| spellingShingle | Aaron S. Schwartz‐Duval Konstantin V. Sokolov Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles Advanced Science bioimaging biomineralization gold nanoparticles in situ therapy theragnostic |
| title | Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles |
| title_full | Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles |
| title_fullStr | Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles |
| title_full_unstemmed | Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles |
| title_short | Prospecting Cellular Gold Nanoparticle Biomineralization as a Viable Alternative to Prefabricated Gold Nanoparticles |
| title_sort | prospecting cellular gold nanoparticle biomineralization as a viable alternative to prefabricated gold nanoparticles |
| topic | bioimaging biomineralization gold nanoparticles in situ therapy theragnostic |
| url | https://doi.org/10.1002/advs.202105957 |
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