The association between plasma D-dimer levels and community-acquired pneumonia
BACKGROUND: Plasma D-dimer levels are directly related to the intra- and extra-vascular coagulation that occurs in acute and chronic lung damage in patients with community-acquired pneumonia (CAP). OBJECTIVES: This study examines the relationship between the severity of community-acquired pneumonia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2010-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000600006 |
| _version_ | 1818119323716157440 |
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| author | Sulhattin Arslan Serdal Ugurlu Gokten Bulut Ibrahim Akkurt |
| author_facet | Sulhattin Arslan Serdal Ugurlu Gokten Bulut Ibrahim Akkurt |
| author_sort | Sulhattin Arslan |
| collection | DOAJ |
| description | BACKGROUND: Plasma D-dimer levels are directly related to the intra- and extra-vascular coagulation that occurs in acute and chronic lung damage in patients with community-acquired pneumonia (CAP). OBJECTIVES: This study examines the relationship between the severity of community-acquired pneumonia and D-dimer levels. In addition, the study examines the correlations among community-acquired pneumonia, the radiological extent of the disease and mortality. METHODS: The Pneumonia Severity Index was used to classify patients into five groups. Patients were treated at home or in the hospital according to the guidelines for community-acquired pneumonia. Blood samples were taken from the antecubital vein with an injector and placed into citrated tubes. After they were centrifuged, the samples were evaluated with the quantitative latex method. RESULTS: The study included 60 patients who had been diagnosed with community-acquired pneumonia (mean age 62.5 ± 11.7) and 24 healthy controls (mean age 59.63 ± 6.63). The average plasma D-dimer levels were 337.3 ± 195.1ng/mL in the outpatient treatment group, 691.0 ± 180.5 in the inpatient treatment group, 1363.2 ± 331.5 ng/mLin the intensive care treatment group and 161.3 ± 38.1ng/mL in the control group (p<0.001). The mean D-dimer plasma level was 776.1 ± 473.5ng/mL in patients with an accompanying disease and 494.2 ± 280.1 ng/mL in patients without an accompanying disease (p<0.05). CONCLUSIONS: Plasma D-dimer levels were increased even in community-acquired pneumonia patients who did not have an accompanying disease that would normally cause such an increase. |
| first_indexed | 2024-12-11T05:08:23Z |
| format | Article |
| id | doaj.art-86c492af506249a58c30e6c6029602c8 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T05:08:23Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-86c492af506249a58c30e6c6029602c82022-12-22T01:19:58ZengElsevier EspañaClinics1807-59321980-53222010-01-0165659359710.1590/S1807-59322010000600006The association between plasma D-dimer levels and community-acquired pneumoniaSulhattin ArslanSerdal UgurluGokten BulutIbrahim AkkurtBACKGROUND: Plasma D-dimer levels are directly related to the intra- and extra-vascular coagulation that occurs in acute and chronic lung damage in patients with community-acquired pneumonia (CAP). OBJECTIVES: This study examines the relationship between the severity of community-acquired pneumonia and D-dimer levels. In addition, the study examines the correlations among community-acquired pneumonia, the radiological extent of the disease and mortality. METHODS: The Pneumonia Severity Index was used to classify patients into five groups. Patients were treated at home or in the hospital according to the guidelines for community-acquired pneumonia. Blood samples were taken from the antecubital vein with an injector and placed into citrated tubes. After they were centrifuged, the samples were evaluated with the quantitative latex method. RESULTS: The study included 60 patients who had been diagnosed with community-acquired pneumonia (mean age 62.5 ± 11.7) and 24 healthy controls (mean age 59.63 ± 6.63). The average plasma D-dimer levels were 337.3 ± 195.1ng/mL in the outpatient treatment group, 691.0 ± 180.5 in the inpatient treatment group, 1363.2 ± 331.5 ng/mLin the intensive care treatment group and 161.3 ± 38.1ng/mL in the control group (p<0.001). The mean D-dimer plasma level was 776.1 ± 473.5ng/mL in patients with an accompanying disease and 494.2 ± 280.1 ng/mL in patients without an accompanying disease (p<0.05). CONCLUSIONS: Plasma D-dimer levels were increased even in community-acquired pneumonia patients who did not have an accompanying disease that would normally cause such an increase.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000600006D-dimerCommunity-acquired pneumoniaPneumonia severity |
| spellingShingle | Sulhattin Arslan Serdal Ugurlu Gokten Bulut Ibrahim Akkurt The association between plasma D-dimer levels and community-acquired pneumonia Clinics D-dimer Community-acquired pneumonia Pneumonia severity |
| title | The association between plasma D-dimer levels and community-acquired pneumonia |
| title_full | The association between plasma D-dimer levels and community-acquired pneumonia |
| title_fullStr | The association between plasma D-dimer levels and community-acquired pneumonia |
| title_full_unstemmed | The association between plasma D-dimer levels and community-acquired pneumonia |
| title_short | The association between plasma D-dimer levels and community-acquired pneumonia |
| title_sort | association between plasma d dimer levels and community acquired pneumonia |
| topic | D-dimer Community-acquired pneumonia Pneumonia severity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000600006 |
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