Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy
Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-02-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2019.1667496 |
| _version_ | 1827816859526758400 |
|---|---|
| author | Deborah Elzita do Carmo Corrêa Christiane Maria Ayo Jeane Eliete Laguila Visentainer Eliane Papa Ambrosio-Albuquerque Pâmela Guimarães Reis Cinara Cássia Brandão de Mattos Reinaldo Bulgarelli Bestetti Luiz Carlos de Mattos Ana Maria Sell |
| author_facet | Deborah Elzita do Carmo Corrêa Christiane Maria Ayo Jeane Eliete Laguila Visentainer Eliane Papa Ambrosio-Albuquerque Pâmela Guimarães Reis Cinara Cássia Brandão de Mattos Reinaldo Bulgarelli Bestetti Luiz Carlos de Mattos Ana Maria Sell |
| author_sort | Deborah Elzita do Carmo Corrêa |
| collection | DOAJ |
| description | Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2, HPA-3, HPA-5 and HPA-15, in the severity of left ventricular systolic dysfunction (LVSD) in CCC patients. For this, 229 CCC patients were separated into three groups: without LVSD, mild/moderate LVSD and severe LVSD. PCR-SSP was performed for HPA genotyping and the risk was assessed using SNPStats software. HPA-1 allele and genotype frequencies were lower in mild/moderate LVSD patients compared to other groups, without statistical significance. After stratified analyzes, the HPA-3a/3b genotype frequency was lower in women with severe LVSD compared to those without LVSD (OR:0.29; 95% CI: 0.10–0.84). In conclusion, HPA-3 variant could be a protection factor for CCC in the female patients. |
| first_indexed | 2024-03-12T00:26:21Z |
| format | Article |
| id | doaj.art-86c57b0927d046dda7105cea09370b57 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:21Z |
| publishDate | 2020-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-86c57b0927d046dda7105cea09370b572023-09-15T10:32:02ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-02-0131227227510.1080/09537104.2019.16674961667496Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathyDeborah Elzita do Carmo Corrêa0Christiane Maria Ayo1Jeane Eliete Laguila Visentainer2Eliane Papa Ambrosio-Albuquerque3Pâmela Guimarães Reis4Cinara Cássia Brandão de Mattos5Reinaldo Bulgarelli Bestetti6Luiz Carlos de Mattos7Ana Maria Sell8Maringá State UniversityFaculdade de Medicina de São José do Rio Preto, São Jose do Rio PretoMaringá State UniversityCell Biology and Genetics, Maringa State UniversityMaringá State UniversityFaculdade de Medicina de São José do Rio Preto, São Jose do Rio PretoUniversidade de Ribeirão Preto, Ribeirão PretoFaculdade de Medicina de São José do Rio Preto, São Jose do Rio PretoMaringá State UniversityHuman platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2, HPA-3, HPA-5 and HPA-15, in the severity of left ventricular systolic dysfunction (LVSD) in CCC patients. For this, 229 CCC patients were separated into three groups: without LVSD, mild/moderate LVSD and severe LVSD. PCR-SSP was performed for HPA genotyping and the risk was assessed using SNPStats software. HPA-1 allele and genotype frequencies were lower in mild/moderate LVSD patients compared to other groups, without statistical significance. After stratified analyzes, the HPA-3a/3b genotype frequency was lower in women with severe LVSD compared to those without LVSD (OR:0.29; 95% CI: 0.10–0.84). In conclusion, HPA-3 variant could be a protection factor for CCC in the female patients.http://dx.doi.org/10.1080/09537104.2019.1667496chagas diseasegenetic association studiesgenotyping techniquehuman platelet antigenssnps |
| spellingShingle | Deborah Elzita do Carmo Corrêa Christiane Maria Ayo Jeane Eliete Laguila Visentainer Eliane Papa Ambrosio-Albuquerque Pâmela Guimarães Reis Cinara Cássia Brandão de Mattos Reinaldo Bulgarelli Bestetti Luiz Carlos de Mattos Ana Maria Sell Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy Platelets chagas disease genetic association studies genotyping technique human platelet antigens snps |
| title | Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy |
| title_full | Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy |
| title_fullStr | Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy |
| title_full_unstemmed | Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy |
| title_short | Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy |
| title_sort | human platelet antigen polymorphisms and the risk of chronic chagas disease cardiomyopathy |
| topic | chagas disease genetic association studies genotyping technique human platelet antigens snps |
| url | http://dx.doi.org/10.1080/09537104.2019.1667496 |
| work_keys_str_mv | AT deborahelzitadocarmocorrea humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT christianemariaayo humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT jeaneelietelaguilavisentainer humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT elianepapaambrosioalbuquerque humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT pamelaguimaraesreis humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT cinaracassiabrandaodemattos humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT reinaldobulgarellibestetti humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT luizcarlosdemattos humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy AT anamariasell humanplateletantigenpolymorphismsandtheriskofchronicchagasdiseasecardiomyopathy |