Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study
Abstract It is unclear whether there are different body mass index (BMI) trajectories among a population with normal BMI levels, and the association between BMI patterns and incident hypertension is not well characterized. This prospective cohort study includes surveys conducted at baseline and thre...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14241 |
| _version_ | 1827778965647917056 |
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| author | Jiahui Xu Rui Zhang Rongrong Guo Yali Wang Yue Dai Yanxia Xie Jia Zheng Zhaoqing Sun Liying Xing Yingxian Sun Liqiang Zheng |
| author_facet | Jiahui Xu Rui Zhang Rongrong Guo Yali Wang Yue Dai Yanxia Xie Jia Zheng Zhaoqing Sun Liying Xing Yingxian Sun Liqiang Zheng |
| author_sort | Jiahui Xu |
| collection | DOAJ |
| description | Abstract It is unclear whether there are different body mass index (BMI) trajectories among a population with normal BMI levels, and the association between BMI patterns and incident hypertension is not well characterized. This prospective cohort study includes surveys conducted at baseline and three follow‐ups. 3939 participants who are free of hypertension at baseline or first two follow‐ups were enrolled. At baseline, the age of participants ranged from 35 to 82 years and the mean age was 45.9 years. The BMI trajectories were identified using latent mixture modeling with data from the baseline and first two follow‐ups. The effects of different BMI trajectories on the development of hypertension were analyzed using a Cox proportional hazard model. Four distinct BMI trajectories were identified over the study period (2004‐2010): normal‐stable (n = 1456), normal‐increasing (n = 2159), normal‐fluctuated (n = 166), and normal‐sharp‐increasing (n = 158). Relative to the normal‐stable BMI group, the hazard ratios (HRs) and 95% confidence intervals (CIs) after adjustment for confounding factors of the normal‐increasing, normal‐fluctuated, and normal‐sharp‐increasing groups were 1.244 (1.103‐1.402), 1.331 (1.008‐1.756), and 1.641 (1.257‐2.142), respectively. Additionally, subgroup analysis showed that the normal‐fluctuated BMI trajectory was associated with a significantly higher risk of hypertension only in women (HR = 1.362; 95% CI = 1.151‐1.611). The BMI trajectories were significant predictors of hypertension incidence, and increasing BMI trajectories within the currently designated normal range were associated with an increased hypertension risk, especially in women. |
| first_indexed | 2024-03-11T14:43:29Z |
| format | Article |
| id | doaj.art-86c5d1d1272c47e6ba68abfd4b55f9b2 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:29Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-86c5d1d1272c47e6ba68abfd4b55f9b22023-10-30T13:26:08ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-06-012361212122010.1111/jch.14241Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort studyJiahui Xu0Rui Zhang1Rongrong Guo2Yali Wang3Yue Dai4Yanxia Xie5Jia Zheng6Zhaoqing Sun7Liying Xing8Yingxian Sun9Liqiang Zheng10Department of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaCollege of Public Health Shanghai University of Medicine and Health Sciences Shanghai ChinaDepartment of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Cardiology Shengjing Hospital of China Medical University Shenyang ChinaInstitute of Chronic Disease Liaoning Provincial Center for Disease Control and Prevention Shenyang ChinaDepartment of Cardiology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Cardiology Department of Library and Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang ChinaAbstract It is unclear whether there are different body mass index (BMI) trajectories among a population with normal BMI levels, and the association between BMI patterns and incident hypertension is not well characterized. This prospective cohort study includes surveys conducted at baseline and three follow‐ups. 3939 participants who are free of hypertension at baseline or first two follow‐ups were enrolled. At baseline, the age of participants ranged from 35 to 82 years and the mean age was 45.9 years. The BMI trajectories were identified using latent mixture modeling with data from the baseline and first two follow‐ups. The effects of different BMI trajectories on the development of hypertension were analyzed using a Cox proportional hazard model. Four distinct BMI trajectories were identified over the study period (2004‐2010): normal‐stable (n = 1456), normal‐increasing (n = 2159), normal‐fluctuated (n = 166), and normal‐sharp‐increasing (n = 158). Relative to the normal‐stable BMI group, the hazard ratios (HRs) and 95% confidence intervals (CIs) after adjustment for confounding factors of the normal‐increasing, normal‐fluctuated, and normal‐sharp‐increasing groups were 1.244 (1.103‐1.402), 1.331 (1.008‐1.756), and 1.641 (1.257‐2.142), respectively. Additionally, subgroup analysis showed that the normal‐fluctuated BMI trajectory was associated with a significantly higher risk of hypertension only in women (HR = 1.362; 95% CI = 1.151‐1.611). The BMI trajectories were significant predictors of hypertension incidence, and increasing BMI trajectories within the currently designated normal range were associated with an increased hypertension risk, especially in women.https://doi.org/10.1111/jch.14241body mass indexepidemiologyhypertensionprospective cohort studytrajectory |
| spellingShingle | Jiahui Xu Rui Zhang Rongrong Guo Yali Wang Yue Dai Yanxia Xie Jia Zheng Zhaoqing Sun Liying Xing Yingxian Sun Liqiang Zheng Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study The Journal of Clinical Hypertension body mass index epidemiology hypertension prospective cohort study trajectory |
| title | Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study |
| title_full | Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study |
| title_fullStr | Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study |
| title_full_unstemmed | Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study |
| title_short | Trajectories of body mass index and risk of incident hypertension among a normal body mass index population: A prospective cohort study |
| title_sort | trajectories of body mass index and risk of incident hypertension among a normal body mass index population a prospective cohort study |
| topic | body mass index epidemiology hypertension prospective cohort study trajectory |
| url | https://doi.org/10.1111/jch.14241 |
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