Vaccine development for leptospirosis: A systematic review
Objective: To assess the efficacy of various types of vaccines developed for leptospirosis. Methods: A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=12;spage=533;epage=545;aulast=Surendran |
| _version_ | 1797246461089415168 |
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| author | Yocyny Surendran Mahalingam Nandikha Syafinaz Amin-Nordin Sandeep Kumar Dhanda Mohamad Ridhuan Mohd Ali Narcisse MS Joseph |
| author_facet | Yocyny Surendran Mahalingam Nandikha Syafinaz Amin-Nordin Sandeep Kumar Dhanda Mohamad Ridhuan Mohd Ali Narcisse MS Joseph |
| author_sort | Yocyny Surendran |
| collection | DOAJ |
| description | Objective: To assess the efficacy of various types of vaccines developed for leptospirosis.
Methods: A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria are all Leptospira species regardless of any cluster (pathogenic, intermediate and non-pathogenic). This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine candidates. The studies on the effectiveness of outer membrane protein as vaccine candidates were also included. The articles obtained in the databases were imported into the WPS spreadsheet, and duplicate documents were removed manually.
Results: A total of 24 studies were included in the review, which evaluated various types of leptospirosis vaccines. Multiple vaccines were developed and tested; however, the heterogeneity of Leptospira species pose a challenge. As an effective approach, an epitope based vaccine shows quite a promising result. However, sufficient validation, testing and clinical trials are required.
Conclusions: Developing an effective vaccine for leptospirosis remains a global health priority. While significant progress has been made in recent years, there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations. |
| first_indexed | 2024-04-24T19:43:10Z |
| format | Article |
| id | doaj.art-86c5e32f753642c9a2a6527150d379a2 |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-04-24T19:43:10Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-86c5e32f753642c9a2a6527150d379a22024-03-25T10:17:37ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462023-01-01161253354510.4103/1995-7645.391775Vaccine development for leptospirosis: A systematic reviewYocyny SurendranMahalingam NandikhaSyafinaz Amin-NordinSandeep Kumar DhandaMohamad Ridhuan Mohd AliNarcisse MS JosephObjective: To assess the efficacy of various types of vaccines developed for leptospirosis. Methods: A comprehensive search was conducted in three databases: PubMed, Scopus, and Cochrane Library. Two authors (YS and MN) selected the articles based on manual screening. The study eligibility criteria are all Leptospira species regardless of any cluster (pathogenic, intermediate and non-pathogenic). This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine candidates. The studies on the effectiveness of outer membrane protein as vaccine candidates were also included. The articles obtained in the databases were imported into the WPS spreadsheet, and duplicate documents were removed manually. Results: A total of 24 studies were included in the review, which evaluated various types of leptospirosis vaccines. Multiple vaccines were developed and tested; however, the heterogeneity of Leptospira species pose a challenge. As an effective approach, an epitope based vaccine shows quite a promising result. However, sufficient validation, testing and clinical trials are required. Conclusions: Developing an effective vaccine for leptospirosis remains a global health priority. While significant progress has been made in recent years, there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations.http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=12;spage=533;epage=545;aulast=Surendranleptospira; vaccine candidate; outer membrane protein |
| spellingShingle | Yocyny Surendran Mahalingam Nandikha Syafinaz Amin-Nordin Sandeep Kumar Dhanda Mohamad Ridhuan Mohd Ali Narcisse MS Joseph Vaccine development for leptospirosis: A systematic review Asian Pacific Journal of Tropical Medicine leptospira; vaccine candidate; outer membrane protein |
| title | Vaccine development for leptospirosis: A systematic review |
| title_full | Vaccine development for leptospirosis: A systematic review |
| title_fullStr | Vaccine development for leptospirosis: A systematic review |
| title_full_unstemmed | Vaccine development for leptospirosis: A systematic review |
| title_short | Vaccine development for leptospirosis: A systematic review |
| title_sort | vaccine development for leptospirosis a systematic review |
| topic | leptospira; vaccine candidate; outer membrane protein |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=12;spage=533;epage=545;aulast=Surendran |
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