The art of painting chromosome loops
How to get a metre of DNA into a tiny space while preserving its functional characteristics? This question seems easy to pose, but the answer is far from being trivial. Facing this riddle, salvation came from technical improvements in microscopy and in situ hybridisation techniques applied to cytoge...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-01-01
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| Series: | Quantitative Plant Biology |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2632882823000115/type/journal_article |
| _version_ | 1797367551636799488 |
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| author | Alexandre Berr Marie-Edith Chabouté |
| author_facet | Alexandre Berr Marie-Edith Chabouté |
| author_sort | Alexandre Berr |
| collection | DOAJ |
| description | How to get a metre of DNA into a tiny space while preserving its functional characteristics? This question seems easy to pose, but the answer is far from being trivial. Facing this riddle, salvation came from technical improvements in microscopy and in situ hybridisation techniques applied to cytogenetics. Here, we would like to look into the past at one of these pure cytogenetics articles that makes a breakthrough in addressing this question in plant science. Our choice fell on the work published two decades ago by Fransz et al. (2002). Besides the elegant manner in which DNA probes were organised to bring into light the out-looping arrangement of interphase chromosomes in Arabidopsis thaliana nuclei, this article perfectly illustrates that painting is not reserved to the fine art. As for whether emotional expression prioritised by artists can sometimes hide behind scientific empirical evidence, there is only a small step to make to the general case. |
| first_indexed | 2024-03-08T17:18:57Z |
| format | Article |
| id | doaj.art-86c8a0fe5d974f219488334b985f82d6 |
| institution | Directory Open Access Journal |
| issn | 2632-8828 |
| language | English |
| last_indexed | 2024-03-08T17:18:57Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Quantitative Plant Biology |
| spelling | doaj.art-86c8a0fe5d974f219488334b985f82d62024-01-03T09:14:51ZengCambridge University PressQuantitative Plant Biology2632-88282023-01-01410.1017/qpb.2023.11The art of painting chromosome loopsAlexandre Berr0https://orcid.org/0000-0002-1381-9053Marie-Edith Chabouté1https://orcid.org/0000-0001-8688-721XInstitut de Biologie Moléculaire des Plantes (IBMP), CNRS, Université de Strasbourg, Strasbourg, FranceInstitut de Biologie Moléculaire des Plantes (IBMP), CNRS, Université de Strasbourg, Strasbourg, FranceHow to get a metre of DNA into a tiny space while preserving its functional characteristics? This question seems easy to pose, but the answer is far from being trivial. Facing this riddle, salvation came from technical improvements in microscopy and in situ hybridisation techniques applied to cytogenetics. Here, we would like to look into the past at one of these pure cytogenetics articles that makes a breakthrough in addressing this question in plant science. Our choice fell on the work published two decades ago by Fransz et al. (2002). Besides the elegant manner in which DNA probes were organised to bring into light the out-looping arrangement of interphase chromosomes in Arabidopsis thaliana nuclei, this article perfectly illustrates that painting is not reserved to the fine art. As for whether emotional expression prioritised by artists can sometimes hide behind scientific empirical evidence, there is only a small step to make to the general case.https://www.cambridge.org/core/product/identifier/S2632882823000115/type/journal_articleart and sciencechromatin organisationchromosome paintingcytogeneticsinterphase nuclei |
| spellingShingle | Alexandre Berr Marie-Edith Chabouté The art of painting chromosome loops Quantitative Plant Biology art and science chromatin organisation chromosome painting cytogenetics interphase nuclei |
| title | The art of painting chromosome loops |
| title_full | The art of painting chromosome loops |
| title_fullStr | The art of painting chromosome loops |
| title_full_unstemmed | The art of painting chromosome loops |
| title_short | The art of painting chromosome loops |
| title_sort | art of painting chromosome loops |
| topic | art and science chromatin organisation chromosome painting cytogenetics interphase nuclei |
| url | https://www.cambridge.org/core/product/identifier/S2632882823000115/type/journal_article |
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