A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line
Cissus quadrangularis plant from Vitaceae family, native in India. Many parts of this plant have medicinal values but most precious is stem of this plant. In past years number of studies reported their activities and secondary metabolites in Cissus quadrangularis plant and their pharmacological acti...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294223000539 |
| _version_ | 1797732868199284736 |
|---|---|
| author | Sholapuri Payani Matcha Bhaskar Gandham Sandeep Kumar Jangampalli Adi Pradeepkiran |
| author_facet | Sholapuri Payani Matcha Bhaskar Gandham Sandeep Kumar Jangampalli Adi Pradeepkiran |
| author_sort | Sholapuri Payani |
| collection | DOAJ |
| description | Cissus quadrangularis plant from Vitaceae family, native in India. Many parts of this plant have medicinal values but most precious is stem of this plant. In past years number of studies reported their activities and secondary metabolites in Cissus quadrangularis plant and their pharmacological activities and uses in traditional medicine system. It is reported to possess excellent medicinal properties and potent fracture healing properties, antimicrobial, antiulcer, antioxidative, cholinergic activity and beneficial effect on cardiovascular diseases, possesses antiulcer and cytoprotective property in indomethacin-induced gastric mucosal injury. The aim of this study was to determine the qualitative phytochemical analysis, antimicrobial activity, cell viability and in vitro anticancer activity of a potential of Cissus quadrangularis stem extract against A549 human lung cancer cell line. The disc diffusion method was employed to determine the antimicrobial activity of Cissus quadrangularis stem extract and showed potential antibacterial and antifungal activity against various microorganisms. Results have shown that Stem methanolic extract induced a significant decrease of tumour cell viability. The cell viability assay clearly showed that the cells treated with Cissus quadrangularis methanolic extract has significantly reduced the lung cancer cell viability in a dose dependant manner. The stem methanolic extract was tested for the in vitro antiproliferative potential on A549 human lung cancer cell line using different concentrations, namely 1000, 62.5 and 7.8 µg/ml. We observed the IC50 dose at 65.2 μg/ml concentration. In cell culture A549 cells treated with Cissus quadrangularis stem methanolic extract in 24 h the cells growth is controlled. |
| first_indexed | 2024-03-12T12:20:43Z |
| format | Article |
| id | doaj.art-86c8ed74cf484d73aebd80974d7b07b6 |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-03-12T12:20:43Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-86c8ed74cf484d73aebd80974d7b07b62023-08-30T05:54:25ZengElsevierCancer Treatment and Research Communications2468-29422023-01-0136100732A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell lineSholapuri Payani0Matcha Bhaskar1Gandham Sandeep Kumar2Jangampalli Adi Pradeepkiran3Department of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati, Andhra Pradesh, IndiaDepartment of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India; Corresponding author.Department of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati, Andhra Pradesh, IndiaDepartment of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India; Deapartment of Internal Medicine, Texas Tech University of Health Science Centre, Lubbock, TX 79415, USACissus quadrangularis plant from Vitaceae family, native in India. Many parts of this plant have medicinal values but most precious is stem of this plant. In past years number of studies reported their activities and secondary metabolites in Cissus quadrangularis plant and their pharmacological activities and uses in traditional medicine system. It is reported to possess excellent medicinal properties and potent fracture healing properties, antimicrobial, antiulcer, antioxidative, cholinergic activity and beneficial effect on cardiovascular diseases, possesses antiulcer and cytoprotective property in indomethacin-induced gastric mucosal injury. The aim of this study was to determine the qualitative phytochemical analysis, antimicrobial activity, cell viability and in vitro anticancer activity of a potential of Cissus quadrangularis stem extract against A549 human lung cancer cell line. The disc diffusion method was employed to determine the antimicrobial activity of Cissus quadrangularis stem extract and showed potential antibacterial and antifungal activity against various microorganisms. Results have shown that Stem methanolic extract induced a significant decrease of tumour cell viability. The cell viability assay clearly showed that the cells treated with Cissus quadrangularis methanolic extract has significantly reduced the lung cancer cell viability in a dose dependant manner. The stem methanolic extract was tested for the in vitro antiproliferative potential on A549 human lung cancer cell line using different concentrations, namely 1000, 62.5 and 7.8 µg/ml. We observed the IC50 dose at 65.2 μg/ml concentration. In cell culture A549 cells treated with Cissus quadrangularis stem methanolic extract in 24 h the cells growth is controlled.http://www.sciencedirect.com/science/article/pii/S2468294223000539Cissus quadrangularisAntimicrobial activityAnticancer activity |
| spellingShingle | Sholapuri Payani Matcha Bhaskar Gandham Sandeep Kumar Jangampalli Adi Pradeepkiran A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line Cancer Treatment and Research Communications Cissus quadrangularis Antimicrobial activity Anticancer activity |
| title | A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line |
| title_full | A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line |
| title_fullStr | A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line |
| title_full_unstemmed | A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line |
| title_short | A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line |
| title_sort | study on antimicrobial and anticancer properties of cissus quadrangulris using lung cancer cell line |
| topic | Cissus quadrangularis Antimicrobial activity Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2468294223000539 |
| work_keys_str_mv | AT sholapuripayani astudyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT matchabhaskar astudyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT gandhamsandeepkumar astudyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT jangampalliadipradeepkiran astudyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT sholapuripayani studyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT matchabhaskar studyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT gandhamsandeepkumar studyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline AT jangampalliadipradeepkiran studyonantimicrobialandanticancerpropertiesofcissusquadrangulrisusinglungcancercellline |