The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design
Asthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers are known. The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics and the microbiome in severe asthma exacerbations. Here, we present the de...
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MDPI AG
2020-09-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/10/3/123 |
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| author | Javier Perez-Garcia José M. Hernández-Pérez Ruperto González-Pérez Olaia Sardón Elena Martin-Gonzalez Antonio Espuela-Ortiz Elena Mederos-Luis Ariel Callero Esther Herrera-Luis Paula Corcuera Inmaculada Sánchez-Machín Paloma Poza-Guedes Luis Manuel González García Purificación Ramírez-Martín Lorenzo Pérez-Negrín Hemily Izaguirre-Flores Javier Barrios-Recio Eva Pérez-Rodríguez Julia Alcoba-Florez José A. Cañas José M. Rodrigo Muñoz Victoria del Pozo Javier Korta-Murua Lina I. Pérez Méndez Mariano Hernandez-Ferrer Jesús Villar Fabian Lorenzo-Diaz Maria Pino-Yanes |
| author_facet | Javier Perez-Garcia José M. Hernández-Pérez Ruperto González-Pérez Olaia Sardón Elena Martin-Gonzalez Antonio Espuela-Ortiz Elena Mederos-Luis Ariel Callero Esther Herrera-Luis Paula Corcuera Inmaculada Sánchez-Machín Paloma Poza-Guedes Luis Manuel González García Purificación Ramírez-Martín Lorenzo Pérez-Negrín Hemily Izaguirre-Flores Javier Barrios-Recio Eva Pérez-Rodríguez Julia Alcoba-Florez José A. Cañas José M. Rodrigo Muñoz Victoria del Pozo Javier Korta-Murua Lina I. Pérez Méndez Mariano Hernandez-Ferrer Jesús Villar Fabian Lorenzo-Diaz Maria Pino-Yanes |
| author_sort | Javier Perez-Garcia |
| collection | DOAJ |
| description | Asthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers are known. The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics and the microbiome in severe asthma exacerbations. Here, we present the design of GEMAS and the characteristics of patients recruited from March 2018 to March 2020. Different biological samples and demographic and clinical variables were collected from asthma patients recruited by allergy and pulmonary medicine units in several hospitals from Spain. Cases and controls were defined by the presence/absence of severe asthma exacerbations in the past year (oral corticosteroid use, emergency room visits, and/or asthma-related hospitalizations). A total of 137 cases and 120 controls were recruited. After stratifying by recruitment location (i.e., Canary Islands and Basque Country), cases and controls did not differ for most demographic and clinical variables (<i>p</i> > 0.05). However, cases showed a higher proportion of characteristics inherent to asthma exacerbations (impaired lung function, severe disease, uncontrolled asthma, gastroesophageal reflux, and use of asthma medications) compared to controls (<i>p</i> < 0.05). Similar results were found after stratification by recruitment unit. Thereby, asthma patients enrolled in GEMAS are balanced for potential confounders and have clinical characteristics that support the phenotype definition. GEMAS will improve the knowledge of potential biomarkers of asthma exacerbations. |
| first_indexed | 2024-03-10T16:23:39Z |
| format | Article |
| id | doaj.art-86c942cb2ef6455686df437048f25fd5 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T16:23:39Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-86c942cb2ef6455686df437048f25fd52023-11-20T13:28:32ZengMDPI AGJournal of Personalized Medicine2075-44262020-09-0110312310.3390/jpm10030123The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and DesignJavier Perez-Garcia0José M. Hernández-Pérez1Ruperto González-Pérez2Olaia Sardón3Elena Martin-Gonzalez4Antonio Espuela-Ortiz5Elena Mederos-Luis6Ariel Callero7Esther Herrera-Luis8Paula Corcuera9Inmaculada Sánchez-Machín10Paloma Poza-Guedes11Luis Manuel González García12Purificación Ramírez-Martín13Lorenzo Pérez-Negrín14Hemily Izaguirre-Flores15Javier Barrios-Recio16Eva Pérez-Rodríguez17Julia Alcoba-Florez18José A. Cañas19José M. Rodrigo Muñoz20Victoria del Pozo21Javier Korta-Murua22Lina I. Pérez Méndez23Mariano Hernandez-Ferrer24Jesús Villar25Fabian Lorenzo-Diaz26Maria Pino-Yanes27Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainPulmonary Medicine Service, Hospital Universitario de N.S de Candelaria, 38010 Santa Cruz de Tenerife, SpainAllergy Department, Hospital Universitario de Canarias, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainDivision of Pediatric Respiratory Medicine, Hospital Universitario Donostia, 20014 San Sebastián, SpainGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainAllergy Department, Hospital Universitario de Canarias, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainAllergy Unit, Hospital Universitario N.S. de Candelaria, 38010 Santa Cruz de Tenerife, SpainGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainDivision of Pediatric Respiratory Medicine, Hospital Universitario Donostia, 20014 San Sebastián, SpainAllergy Department, Hospital Universitario de Canarias, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainAllergy Department, Hospital Universitario de Canarias, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainPulmonary Medicine Section, Hospital General de La Palma, 38713 Breña alta, Santa Cruz de Tenerife, SpainPulmonary Medicine Service, Hospital Universitario de N.S de Candelaria, 38010 Santa Cruz de Tenerife, SpainPulmonary Medicine Service, Hospital Universitario de N.S de Candelaria, 38010 Santa Cruz de Tenerife, SpainPulmonary Medicine Department, Hospital Universitario de Canarias, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainAllergy Unit, Hospital Universitario N.S. de Candelaria, 38010 Santa Cruz de Tenerife, SpainAllergy Unit, Hospital Universitario N.S. de Candelaria, 38010 Santa Cruz de Tenerife, SpainUnit Service of Microbiology, Hospital Universitario Nuestra Señora de La Candelaria, 38010 Santa Cruz de Tenerife, SpainDepartment of Immunology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartment of Immunology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartment of Immunology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDivision of Pediatric Respiratory Medicine, Hospital Universitario Donostia, 20014 San Sebastián, SpainCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, SpainDepartment of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, SpainGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, SpainAsthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers are known. The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics and the microbiome in severe asthma exacerbations. Here, we present the design of GEMAS and the characteristics of patients recruited from March 2018 to March 2020. Different biological samples and demographic and clinical variables were collected from asthma patients recruited by allergy and pulmonary medicine units in several hospitals from Spain. Cases and controls were defined by the presence/absence of severe asthma exacerbations in the past year (oral corticosteroid use, emergency room visits, and/or asthma-related hospitalizations). A total of 137 cases and 120 controls were recruited. After stratifying by recruitment location (i.e., Canary Islands and Basque Country), cases and controls did not differ for most demographic and clinical variables (<i>p</i> > 0.05). However, cases showed a higher proportion of characteristics inherent to asthma exacerbations (impaired lung function, severe disease, uncontrolled asthma, gastroesophageal reflux, and use of asthma medications) compared to controls (<i>p</i> < 0.05). Similar results were found after stratification by recruitment unit. Thereby, asthma patients enrolled in GEMAS are balanced for potential confounders and have clinical characteristics that support the phenotype definition. GEMAS will improve the knowledge of potential biomarkers of asthma exacerbations.https://www.mdpi.com/2075-4426/10/3/123asthmaexacerbationmicrobiomegeneticsprecision medicinerespiratory disease |
| spellingShingle | Javier Perez-Garcia José M. Hernández-Pérez Ruperto González-Pérez Olaia Sardón Elena Martin-Gonzalez Antonio Espuela-Ortiz Elena Mederos-Luis Ariel Callero Esther Herrera-Luis Paula Corcuera Inmaculada Sánchez-Machín Paloma Poza-Guedes Luis Manuel González García Purificación Ramírez-Martín Lorenzo Pérez-Negrín Hemily Izaguirre-Flores Javier Barrios-Recio Eva Pérez-Rodríguez Julia Alcoba-Florez José A. Cañas José M. Rodrigo Muñoz Victoria del Pozo Javier Korta-Murua Lina I. Pérez Méndez Mariano Hernandez-Ferrer Jesús Villar Fabian Lorenzo-Diaz Maria Pino-Yanes The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design Journal of Personalized Medicine asthma exacerbation microbiome genetics precision medicine respiratory disease |
| title | The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design |
| title_full | The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design |
| title_fullStr | The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design |
| title_full_unstemmed | The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design |
| title_short | The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design |
| title_sort | genomics and metagenomics of asthma severity gemas study rationale and design |
| topic | asthma exacerbation microbiome genetics precision medicine respiratory disease |
| url | https://www.mdpi.com/2075-4426/10/3/123 |
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