Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin‐induced nephrotoxicity (CIN) is believed to occur primarily through mitochondrial damage and reactive oxygen species (ROS) generation. Our previous studies hav...

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Bibliographic Details
Main Authors: Qingqing Li, Xueyan Liang, Yufang Yang, Xian Zeng, Xiaobin Zhong, Chun Huang
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:FEBS Open Bio
Subjects:
cisplatin
HIF‐1α
mitochondria
Panax notoginseng saponins
ROS
Online Access:https://doi.org/10.1002/2211-5463.12760

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