Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study
Abstract Background The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes following hepatic resection (HR) versus transarterial chemoembolization...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4557-5 |
| _version_ | 1818910437644697600 |
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| author | Chong Zhong Yong-Fa Zhang Jun-Hai Huang Cheng-Ming Xiong Zi-Yu Wang Qing-Lian Chen Rong-Ping Guo |
| author_facet | Chong Zhong Yong-Fa Zhang Jun-Hai Huang Cheng-Ming Xiong Zi-Yu Wang Qing-Lian Chen Rong-Ping Guo |
| author_sort | Chong Zhong |
| collection | DOAJ |
| description | Abstract Background The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes following hepatic resection (HR) versus transarterial chemoembolization (TACE) for stage T3 HCC. Methods From 2005 to 2013, 1179 patients with T3 HCC who underwent HR or TACE were divided into two groups, HR group (n = 280) or TACE group (n = 899). The clinical outcomes were compared before and after propensity score matching. Results The propensity model matched 244 patients in each group for further analyses. After matching, medium overall survival (OS), 1, 3, and 5-year OS rates in TACE group were 11.8 (95%CI, 9.9–13.7) months, 49.6, 16.5, and 8.4%, respectively; which in HR group were 17.8 (95% CI, 14.8–20.8) months, 63.1, 33.3, and 26.4%, respectively; (log rank = 19.908, P < 0.01). Patients in HR group were more likely to develop pleural effusion, compared with those in TACE group (0.4% vs. 5.3%, P = 0.01). However, no significant differences in other adverse events (AEs) were found between two groups. Similar results were also demonstrated prior to the matched analysis. Multivariate analysis indicated that prothrombin time (PT), tumor size, tumor numbers, UICC staging status, and initial treatment were independent prognostic factors. Conclusions Our study revealed that TACE was an option for UICC T3 HCC patients. However, HR seemed to be safe and yield a survival benefit compared with TACE, especially for patients with a good underlying liver function. |
| first_indexed | 2024-12-19T22:42:48Z |
| format | Article |
| id | doaj.art-86cf82315e6a460b86dc8445bcf96546 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-19T22:42:48Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-86cf82315e6a460b86dc8445bcf965462022-12-21T20:03:01ZengBMCBMC Cancer1471-24072018-06-0118111010.1186/s12885-018-4557-5Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching studyChong Zhong0Yong-Fa Zhang1Jun-Hai Huang2Cheng-Ming Xiong3Zi-Yu Wang4Qing-Lian Chen5Rong-Ping Guo6Lingnan Medical Research Center, Guangzhou University of Chinese MedicineDepartment of Liver Surgery, Fudan University Shanghai Cancer CenterLingnan Medical Research Center, Guangzhou University of Chinese MedicineThe First Clinical Medical School of Guangzhou University of Chinese MedicineThe First Clinical Medical School of Guangzhou University of Chinese MedicineThe First Clinical Medical School of Guangzhou University of Chinese MedicineDepartment of Hepatobiliary Oncology, Cancer Center of Sun Yat-sen UniversityAbstract Background The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes following hepatic resection (HR) versus transarterial chemoembolization (TACE) for stage T3 HCC. Methods From 2005 to 2013, 1179 patients with T3 HCC who underwent HR or TACE were divided into two groups, HR group (n = 280) or TACE group (n = 899). The clinical outcomes were compared before and after propensity score matching. Results The propensity model matched 244 patients in each group for further analyses. After matching, medium overall survival (OS), 1, 3, and 5-year OS rates in TACE group were 11.8 (95%CI, 9.9–13.7) months, 49.6, 16.5, and 8.4%, respectively; which in HR group were 17.8 (95% CI, 14.8–20.8) months, 63.1, 33.3, and 26.4%, respectively; (log rank = 19.908, P < 0.01). Patients in HR group were more likely to develop pleural effusion, compared with those in TACE group (0.4% vs. 5.3%, P = 0.01). However, no significant differences in other adverse events (AEs) were found between two groups. Similar results were also demonstrated prior to the matched analysis. Multivariate analysis indicated that prothrombin time (PT), tumor size, tumor numbers, UICC staging status, and initial treatment were independent prognostic factors. Conclusions Our study revealed that TACE was an option for UICC T3 HCC patients. However, HR seemed to be safe and yield a survival benefit compared with TACE, especially for patients with a good underlying liver function.http://link.springer.com/article/10.1186/s12885-018-4557-5Hepatocellular carcinomaHepatic resectionTACEPropensity score matching study |
| spellingShingle | Chong Zhong Yong-Fa Zhang Jun-Hai Huang Cheng-Ming Xiong Zi-Yu Wang Qing-Lian Chen Rong-Ping Guo Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study BMC Cancer Hepatocellular carcinoma Hepatic resection TACE Propensity score matching study |
| title | Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study |
| title_full | Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study |
| title_fullStr | Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study |
| title_full_unstemmed | Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study |
| title_short | Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study |
| title_sort | comparison of hepatic resection and transarterial chemoembolization for uicc stage t3 hepatocellular carcinoma a propensity score matching study |
| topic | Hepatocellular carcinoma Hepatic resection TACE Propensity score matching study |
| url | http://link.springer.com/article/10.1186/s12885-018-4557-5 |
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