Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study
Background: Spermidine, a natural polyamine, appears to be a promising intervention for the treatment of obesity in animal studies, but epidemiological studies on the association between spermidine and obesity are inadequate. Methods: In the cross-sectional study, a total of 4230 eligible Chinese ru...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2613 |
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| author | Hanshu Gao Qianlong Zhang Jiahui Xu Wei Yuan Ruixue Li Hui Guo Cuiying Gu Wenjing Feng Yanan Ma Zhaoqing Sun Liqiang Zheng |
| author_facet | Hanshu Gao Qianlong Zhang Jiahui Xu Wei Yuan Ruixue Li Hui Guo Cuiying Gu Wenjing Feng Yanan Ma Zhaoqing Sun Liqiang Zheng |
| author_sort | Hanshu Gao |
| collection | DOAJ |
| description | Background: Spermidine, a natural polyamine, appears to be a promising intervention for the treatment of obesity in animal studies, but epidemiological studies on the association between spermidine and obesity are inadequate. Methods: In the cross-sectional study, a total of 4230 eligible Chinese rural participants aged ≥ 35 years at baseline were recruited, of whom 1738 completed the two-year follow-up. Serum spermidines were measured using high-performance liquid chromatography with a fluorescence detector. Obesity and change in BMI were used as outcomes. Multivariable logistic regression analysis was applied to obtain the odds ratios (ORs) and 95% confidence intervals (CIs). Results: Participants who were obese had higher serum spermidine concentrations than those who were of normal weight (median (IQR), 27.2 ng/mL (14.8–53.4 ng/mL) vs. 23.8 ng/mL (12.8–46.6 ng/mL), <i>p</i> = 0.002). Compared with participants in the first quartile, those in the third quartile (OR 1.327, 95% CI 1.050 to 1.678) and the fourth quartile (OR 1.417, 95% CI 1.121 to 1.791) had a significantly increased risk of prevalent obesity after adjustment for confounding factors. In the follow-up study, participants in the third quartile (OR 0.712, 95% CI 0.535 to 0.946) and the fourth quartile (OR 0.493, 95% CI 0.370 to 0.657) had significantly lower risks of an increase in BMI after adjustment for confounding factors, with the lowest quartile as the reference. Meanwhile, we found a nonlinear relationship between spermidine and BMI in the follow-up study (<i>p</i> < 0.001). Conclusions: Serum spermidine was positively associated with increased odds of obesity in the cross-sectional study but reduced odds of an increase in BMI in the follow-up study among Chinese adults. Future studies are warranted to determine the exact mechanism underlying the association between spermidine and obesity and the scope for interventions. |
| first_indexed | 2024-03-09T10:26:30Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T10:26:30Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-86d411ad2f0e480e975ff76c31c006552023-12-01T21:38:04ZengMDPI AGNutrients2072-66432022-06-011413261310.3390/nu14132613Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up StudyHanshu Gao0Qianlong Zhang1Jiahui Xu2Wei Yuan3Ruixue Li4Hui Guo5Cuiying Gu6Wenjing Feng7Yanan Ma8Zhaoqing Sun9Liqiang Zheng10Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaMinistry of Education—Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Cardiology, Shengjing Hospital of China Medical University, Shenyang 110004, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaBackground: Spermidine, a natural polyamine, appears to be a promising intervention for the treatment of obesity in animal studies, but epidemiological studies on the association between spermidine and obesity are inadequate. Methods: In the cross-sectional study, a total of 4230 eligible Chinese rural participants aged ≥ 35 years at baseline were recruited, of whom 1738 completed the two-year follow-up. Serum spermidines were measured using high-performance liquid chromatography with a fluorescence detector. Obesity and change in BMI were used as outcomes. Multivariable logistic regression analysis was applied to obtain the odds ratios (ORs) and 95% confidence intervals (CIs). Results: Participants who were obese had higher serum spermidine concentrations than those who were of normal weight (median (IQR), 27.2 ng/mL (14.8–53.4 ng/mL) vs. 23.8 ng/mL (12.8–46.6 ng/mL), <i>p</i> = 0.002). Compared with participants in the first quartile, those in the third quartile (OR 1.327, 95% CI 1.050 to 1.678) and the fourth quartile (OR 1.417, 95% CI 1.121 to 1.791) had a significantly increased risk of prevalent obesity after adjustment for confounding factors. In the follow-up study, participants in the third quartile (OR 0.712, 95% CI 0.535 to 0.946) and the fourth quartile (OR 0.493, 95% CI 0.370 to 0.657) had significantly lower risks of an increase in BMI after adjustment for confounding factors, with the lowest quartile as the reference. Meanwhile, we found a nonlinear relationship between spermidine and BMI in the follow-up study (<i>p</i> < 0.001). Conclusions: Serum spermidine was positively associated with increased odds of obesity in the cross-sectional study but reduced odds of an increase in BMI in the follow-up study among Chinese adults. Future studies are warranted to determine the exact mechanism underlying the association between spermidine and obesity and the scope for interventions.https://www.mdpi.com/2072-6643/14/13/2613spermidineobesityoverweightcompensatorychange in BMI |
| spellingShingle | Hanshu Gao Qianlong Zhang Jiahui Xu Wei Yuan Ruixue Li Hui Guo Cuiying Gu Wenjing Feng Yanan Ma Zhaoqing Sun Liqiang Zheng Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study Nutrients spermidine obesity overweight compensatory change in BMI |
| title | Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study |
| title_full | Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study |
| title_fullStr | Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study |
| title_full_unstemmed | Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study |
| title_short | Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study |
| title_sort | elevation of serum spermidine in obese patients results from a cross sectional and follow up study |
| topic | spermidine obesity overweight compensatory change in BMI |
| url | https://www.mdpi.com/2072-6643/14/13/2613 |
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