Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression

Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression

Abstract Background Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. BET family proteins, acting as the “readers” of acetylated modifications on histones, have been linked to transcr...

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Bibliographic Details
Main Authors: Jin Dai, Sheng Zhou, Qiting Ge, Jinzhong Qin, Jianxin Li, Huangxian Ju, Yi Cao, Minghao Zheng, Chaojun Li, Xiang Gao, Huajian Teng, Qing Jiang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Matrix-degrading enzymes
Brd
Transcription
Acetylation
Online Access:http://link.springer.com/article/10.1186/s13018-019-1091-3

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