Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea
Background Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study aims to analyze and understand the characteristics of CUP in Korea according to vir...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2023-05-01
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| Series: | Journal of Pathology and Translational Medicine |
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| Online Access: | http://jpatholtm.org/upload/pdf/jptm-2023-04-12.pdf |
| _version_ | 1797825604746215424 |
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| author | Miseon Lee Uiree Jo Joon Seon Song Youn Soo Lee Chang Gok Woo Dong-Hoon Kim Jung Yeon Kim Sun Och Yoon Kyung-Ja Cho |
| author_facet | Miseon Lee Uiree Jo Joon Seon Song Youn Soo Lee Chang Gok Woo Dong-Hoon Kim Jung Yeon Kim Sun Och Yoon Kyung-Ja Cho |
| author_sort | Miseon Lee |
| collection | DOAJ |
| description | Background Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study aims to analyze and understand the characteristics of CUP in Korea according to viral and p16 and p53 status through a multicenter study. Methods Ninety-five cases of CUP retrieved from six hospitals in Korea between January 2006 and December 2016 were subjected to high-risk HPV detection (DNA in situ hybridization [ISH] or real-time polymerase chain reaction), EBV detection (ISH), and immunohistochemistry for p16 and p53. Results CUP was HPV-related in 37 cases (38.9%), EBV-related in five cases (5.3%), and unrelated to HPV or EBV in 46 cases (48.4%). HPV-related CUP cases had the best overall survival (OS) (p = .004). According to the multivariate analysis, virus-unrelated disease (p = .023) and longer smoking duration (p < .005) were prognostic factors for poor OS. Cystic change (p = .016) and basaloid pattern (p < .001) were more frequent in HPV-related cases, and lymphoepithelial lesion was frequent in EBV-related cases (p = .010). There was no significant association between viral status and p53 positivity (p = .341), smoking status (p = .728), or smoking duration (p = .187). Korean data differ from Western data in the absence of an association among HPV, p53 positivity, and smoking history. Conclusions Virus-unrelated CUP in Korea had the highest frequency among all CUP cases. HPV-related CUP is similar to HPV-mediated oropharyngeal cancer and EBVrelated CUP is similar to nasopharyngeal cancer in terms of characteristics, respectively. |
| first_indexed | 2024-03-13T10:56:24Z |
| format | Article |
| id | doaj.art-86d50f3f0c514606a3f57f0d7584fe9e |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-03-13T10:56:24Z |
| publishDate | 2023-05-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-86d50f3f0c514606a3f57f0d7584fe9e2023-05-17T04:26:00ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452023-05-0157316617710.4132/jptm.2023.04.1217068Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in KoreaMiseon Lee0Uiree Jo1Joon Seon Song2Youn Soo Lee3Chang Gok Woo4Dong-Hoon Kim5Jung Yeon Kim6Sun Och Yoon7Kyung-Ja Cho8 Department of Pathology, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Pathology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Pathology, Inje University Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study aims to analyze and understand the characteristics of CUP in Korea according to viral and p16 and p53 status through a multicenter study. Methods Ninety-five cases of CUP retrieved from six hospitals in Korea between January 2006 and December 2016 were subjected to high-risk HPV detection (DNA in situ hybridization [ISH] or real-time polymerase chain reaction), EBV detection (ISH), and immunohistochemistry for p16 and p53. Results CUP was HPV-related in 37 cases (38.9%), EBV-related in five cases (5.3%), and unrelated to HPV or EBV in 46 cases (48.4%). HPV-related CUP cases had the best overall survival (OS) (p = .004). According to the multivariate analysis, virus-unrelated disease (p = .023) and longer smoking duration (p < .005) were prognostic factors for poor OS. Cystic change (p = .016) and basaloid pattern (p < .001) were more frequent in HPV-related cases, and lymphoepithelial lesion was frequent in EBV-related cases (p = .010). There was no significant association between viral status and p53 positivity (p = .341), smoking status (p = .728), or smoking duration (p = .187). Korean data differ from Western data in the absence of an association among HPV, p53 positivity, and smoking history. Conclusions Virus-unrelated CUP in Korea had the highest frequency among all CUP cases. HPV-related CUP is similar to HPV-mediated oropharyngeal cancer and EBVrelated CUP is similar to nasopharyngeal cancer in terms of characteristics, respectively.http://jpatholtm.org/upload/pdf/jptm-2023-04-12.pdfunknown primary neoplasmslymph node metastasishuman papillomavirus virusepstein-barr virus infections |
| spellingShingle | Miseon Lee Uiree Jo Joon Seon Song Youn Soo Lee Chang Gok Woo Dong-Hoon Kim Jung Yeon Kim Sun Och Yoon Kyung-Ja Cho Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea Journal of Pathology and Translational Medicine unknown primary neoplasms lymph node metastasis human papillomavirus virus epstein-barr virus infections |
| title | Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea |
| title_full | Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea |
| title_fullStr | Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea |
| title_full_unstemmed | Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea |
| title_short | Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea |
| title_sort | clinicopathologic characterization of cervical metastasis from an unknown primary tumor a multicenter study in korea |
| topic | unknown primary neoplasms lymph node metastasis human papillomavirus virus epstein-barr virus infections |
| url | http://jpatholtm.org/upload/pdf/jptm-2023-04-12.pdf |
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