Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses
PurposeThis work demonstrates significant advantages in ophthalmic surgeries through the use of picosecond ultrashort laser pulses instead of state-of-the-art nanosecond laser pulses. These ultrashort lasers shall serve as universal tools more effectively combining advantages of high precision, low...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1345976/full |
| _version_ | 1797321039870427136 |
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| author | Michael Körber Michael Körber Jakob Fellinger Milan Fritsche Andreas Giese Konstantina Kostourou Daniel Kopf Manfred Kottcke Francesco Luciani Josef M. Schmidbauer Josef M. Schmidbauer Jonathan Wenk Bernd Braun |
| author_facet | Michael Körber Michael Körber Jakob Fellinger Milan Fritsche Andreas Giese Konstantina Kostourou Daniel Kopf Manfred Kottcke Francesco Luciani Josef M. Schmidbauer Josef M. Schmidbauer Jonathan Wenk Bernd Braun |
| author_sort | Michael Körber |
| collection | DOAJ |
| description | PurposeThis work demonstrates significant advantages in ophthalmic surgeries through the use of picosecond ultrashort laser pulses instead of state-of-the-art nanosecond laser pulses. These ultrashort lasers shall serve as universal tools more effectively combining advantages of high precision, low impact and economic advantages compared to existing instruments.MethodsAs samples, we used post-mortem porcine eyes on which we performed the experiments with both picosecond and nanosecond lasers. Performed surgeries were laser iridotomy, (post-) cataract treatment/capsulotomy and selective laser-trabeculoplasty. Pulse widths were between 12 ps and 220 ns with pulse energies between 30 μJ and 10 mJ at 532 nm and 1,064 nm. Additionally, we investigated accompanying shock waves, cavitation bubbles, and heat effects during the ablation processes.ResultsFor all surgeries, significant differences were observed between picosecond and nanosecond pulses: It was possible to scale the pulse energy down to 10 of microjoules rather than requiring millijoules, and resulting tissue ablations are much more precise, more deterministic and less frayed. The shock wave and cavitation bubble investigation revealed major differences in pressure between picosecond pulses (0.25 MPa, 50 μJ) and nanosecond pulses (37 MPa, 5 mJ). The heat input during ablation could be lowered by two orders of magnitude.ConclusionPicosecond ultrashort laser pulses show substantial benefits for several ophthalmic surgeries, with regard to ablation precision, shock wave generation and heat input. They are better than state-of-the-art ophthalmic nanosecond lasers in all aspects tested. |
| first_indexed | 2024-03-08T04:51:46Z |
| format | Article |
| id | doaj.art-86d51b8a0e5842eba1b33dd74ab094b1 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-08T04:51:46Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-86d51b8a0e5842eba1b33dd74ab094b12024-02-08T04:37:47ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-02-011110.3389/fmed.2024.13459761345976Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulsesMichael Körber0Michael Körber1Jakob Fellinger2Milan Fritsche3Andreas Giese4Konstantina Kostourou5Daniel Kopf6Manfred Kottcke7Francesco Luciani8Josef M. Schmidbauer9Josef M. Schmidbauer10Jonathan Wenk11Bernd Braun12Applied Mathematics, Physics and Humanities, Nuremberg Institute of Technology, Nuremberg, GermanyParacelsus Medical University, Nuremberg, GermanyMONTFORT Laser GmbH, Götzis, AustriaApplied Mathematics, Physics and Humanities, Nuremberg Institute of Technology, Nuremberg, GermanyApplied Mathematics, Physics and Humanities, Nuremberg Institute of Technology, Nuremberg, GermanyNANEO Precision IBS Coatings GmbH, Lindau, GermanyMONTFORT Laser GmbH, Götzis, AustriaApplied Mathematics, Physics and Humanities, Nuremberg Institute of Technology, Nuremberg, GermanyClinic of Ophthalmology, Klinikum Nürnberg Nord, Nuremberg, GermanyParacelsus Medical University, Nuremberg, GermanyClinic of Ophthalmology, Klinikum Nürnberg Nord, Nuremberg, GermanyApplied Mathematics, Physics and Humanities, Nuremberg Institute of Technology, Nuremberg, GermanyApplied Mathematics, Physics and Humanities, Nuremberg Institute of Technology, Nuremberg, GermanyPurposeThis work demonstrates significant advantages in ophthalmic surgeries through the use of picosecond ultrashort laser pulses instead of state-of-the-art nanosecond laser pulses. These ultrashort lasers shall serve as universal tools more effectively combining advantages of high precision, low impact and economic advantages compared to existing instruments.MethodsAs samples, we used post-mortem porcine eyes on which we performed the experiments with both picosecond and nanosecond lasers. Performed surgeries were laser iridotomy, (post-) cataract treatment/capsulotomy and selective laser-trabeculoplasty. Pulse widths were between 12 ps and 220 ns with pulse energies between 30 μJ and 10 mJ at 532 nm and 1,064 nm. Additionally, we investigated accompanying shock waves, cavitation bubbles, and heat effects during the ablation processes.ResultsFor all surgeries, significant differences were observed between picosecond and nanosecond pulses: It was possible to scale the pulse energy down to 10 of microjoules rather than requiring millijoules, and resulting tissue ablations are much more precise, more deterministic and less frayed. The shock wave and cavitation bubble investigation revealed major differences in pressure between picosecond pulses (0.25 MPa, 50 μJ) and nanosecond pulses (37 MPa, 5 mJ). The heat input during ablation could be lowered by two orders of magnitude.ConclusionPicosecond ultrashort laser pulses show substantial benefits for several ophthalmic surgeries, with regard to ablation precision, shock wave generation and heat input. They are better than state-of-the-art ophthalmic nanosecond lasers in all aspects tested.https://www.frontiersin.org/articles/10.3389/fmed.2024.1345976/fulliridotomycapsulotomySLTpicosecond lasershock wavesglaucoma |
| spellingShingle | Michael Körber Michael Körber Jakob Fellinger Milan Fritsche Andreas Giese Konstantina Kostourou Daniel Kopf Manfred Kottcke Francesco Luciani Josef M. Schmidbauer Josef M. Schmidbauer Jonathan Wenk Bernd Braun Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses Frontiers in Medicine iridotomy capsulotomy SLT picosecond laser shock waves glaucoma |
| title | Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses |
| title_full | Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses |
| title_fullStr | Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses |
| title_full_unstemmed | Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses |
| title_short | Ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses |
| title_sort | ophthalmic surgeries on post mortem porcine eyes with picosecond ultrashort laser pulses |
| topic | iridotomy capsulotomy SLT picosecond laser shock waves glaucoma |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1345976/full |
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