Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal functio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.919773/full |
| _version_ | 1811242292876410880 |
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| author | Kaitlin C. Reeves Kaitlin C. Reeves Nikhil Shah Nikhil Shah Braulio Muñoz Brady K. Atwood Brady K. Atwood |
| author_facet | Kaitlin C. Reeves Kaitlin C. Reeves Nikhil Shah Nikhil Shah Braulio Muñoz Brady K. Atwood Brady K. Atwood |
| author_sort | Kaitlin C. Reeves |
| collection | DOAJ |
| description | Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function and synaptic transmission is not uniform in expression pattern and mechanism across the brain. The localization of receptors within specific cell types and neurocircuits determine the effects that endogenous and exogenous opioids have on brain function. In this review we will explore the similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions. We discuss how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function. |
| first_indexed | 2024-04-12T13:49:34Z |
| format | Article |
| id | doaj.art-86d53687ada64a289d16d8c481d8ddfc |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-12T13:49:34Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-86d53687ada64a289d16d8c481d8ddfc2022-12-22T03:30:34ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-06-011510.3389/fnmol.2022.919773919773Opioid Receptor-Mediated Regulation of Neurotransmission in the BrainKaitlin C. Reeves0Kaitlin C. Reeves1Nikhil Shah2Nikhil Shah3Braulio Muñoz4Brady K. Atwood5Brady K. Atwood6Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United StatesMedical Scientist Training Program, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United StatesStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United StatesOpioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function and synaptic transmission is not uniform in expression pattern and mechanism across the brain. The localization of receptors within specific cell types and neurocircuits determine the effects that endogenous and exogenous opioids have on brain function. In this review we will explore the similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions. We discuss how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function.https://www.frontiersin.org/articles/10.3389/fnmol.2022.919773/fullopioidsynaptic plasticityreceptor signal transductionneurotransmissionglutamateGABA |
| spellingShingle | Kaitlin C. Reeves Kaitlin C. Reeves Nikhil Shah Nikhil Shah Braulio Muñoz Brady K. Atwood Brady K. Atwood Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain Frontiers in Molecular Neuroscience opioid synaptic plasticity receptor signal transduction neurotransmission glutamate GABA |
| title | Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain |
| title_full | Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain |
| title_fullStr | Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain |
| title_full_unstemmed | Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain |
| title_short | Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain |
| title_sort | opioid receptor mediated regulation of neurotransmission in the brain |
| topic | opioid synaptic plasticity receptor signal transduction neurotransmission glutamate GABA |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.919773/full |
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