SppI Forms a Membrane Protein Complex with SppA and Inhibits Its Protease Activity in <named-content content-type="genus-species">Bacillus subtilis</named-content>

SppI Forms a Membrane Protein Complex with SppA and Inhibits Its Protease Activity in <named-content content-type="genus-species">Bacillus subtilis</named-content>

ABSTRACT The membrane protease SppA of Bacillus subtilis was first described as a signal peptide peptidase and later shown to confer resistance to lantibiotics. Here, we report that SppA forms octameric complexes with YteJ, a membrane protein of thus-far-unknown function. Interestingly, sppA and yte...

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Bibliographic Details
Main Authors: Gabriela Henriques, Stephen McGovern, Jolanda Neef, Minia Antelo-Varela, Friedrich Götz, Andreas Otto, Dörte Becher, Jan Maarten van Dijl, Matthieu Jules, Olivier Delumeau
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mSphere
Subjects:
Bacillus subtilis
signal peptide peptidase
lantibiotic resistance
membrane protein complex
enzymatic regulation
proteases
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00724-20

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