Lattice Radiation Therapy in clinical practice: A systematic review
Purpose: Lattice radiation therapy (LRT) is an innovative type of spatially fractionated radiation therapy. It aims to increase large tumors control probability by administering ablative doses without an increased toxicity. Considering the rising number of positive clinical experiences, the objectiv...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630822001276 |
| _version_ | 1811162742541778944 |
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| author | Federico Iori Anna Cappelli Elisa D'Angelo Salvatore Cozzi Sebastiano Finocchi Ghersi Francesca De Felice Patrizia Ciammella Alessio Bruni Cinzia Iotti |
| author_facet | Federico Iori Anna Cappelli Elisa D'Angelo Salvatore Cozzi Sebastiano Finocchi Ghersi Francesca De Felice Patrizia Ciammella Alessio Bruni Cinzia Iotti |
| author_sort | Federico Iori |
| collection | DOAJ |
| description | Purpose: Lattice radiation therapy (LRT) is an innovative type of spatially fractionated radiation therapy. It aims to increase large tumors control probability by administering ablative doses without an increased toxicity. Considering the rising number of positive clinical experiences, the objective of this work is to evaluate LRT safety and efficacy. Method: Reports about LRT clinical experience were identified with a systematic review conducted on four different databases (namely, Medline, Embase, Scopus, and Cochrane Library) through the August 2022. Only LRT clinical reports published in English and with the access to the full manuscript text were considered as eligible. The 2020 update version PRISMA statement was followed. Results: Data extraction was performed from 12 eligible records encompassing 7 case reports, 1 case series, and 4 clinical studies. 81 patients (84 lesions) with a large lesion ranging from 63.2 cc to 3713.5 cc were subjected to exclusive, hybrid, and metabolism guided LRT. Excluding two very severe toxicity with a questionable relation with LRT, available clinical experience seem to confirm LRT safety. When a complete response was not achieved 3–6 months after LRT, a median lesion reduction approximately ≥50 % was registered. Conclusion: This systematic review appear to suggest LRT safety, especially for exclusive LRT. The very low level of evidence and the studies heterogeneity preclude drawing definitive conclusions on LRT efficacy, even though an interesting trend in terms of lesions reduction has been described. |
| first_indexed | 2024-04-10T06:34:10Z |
| format | Article |
| id | doaj.art-86d640a503d144e7bb41477c698d6821 |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-04-10T06:34:10Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-86d640a503d144e7bb41477c698d68212023-03-01T04:32:16ZengElsevierClinical and Translational Radiation Oncology2405-63082023-03-0139100569Lattice Radiation Therapy in clinical practice: A systematic reviewFederico Iori0Anna Cappelli1Elisa D'Angelo2Salvatore Cozzi3Sebastiano Finocchi Ghersi4Francesca De Felice5Patrizia Ciammella6Alessio Bruni7Cinzia Iotti8Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42124 Reggio Emilia, Italy; Corresponding author at: Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, Via Giovanni Amendola, 2, 42122 Reggio Emilia, RE, Italy.Radiotherapy Unit, Azienda Ospedaliero Universitaria di Modena, 41121 Modena, ItalyRadiotherapy Unit, Azienda Ospedaliero Universitaria di Modena, 41121 Modena, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42124 Reggio Emilia, ItalyRadiation Oncolgy Unit, AOU Sant'Andrea, Facoltà di Medicina e Psicologia, Università La Sapienza, 00185 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42124 Reggio Emilia, ItalyRadiotherapy Unit, Azienda Ospedaliero Universitaria di Modena, 41121 Modena, ItalyRadiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42124 Reggio Emilia, ItalyPurpose: Lattice radiation therapy (LRT) is an innovative type of spatially fractionated radiation therapy. It aims to increase large tumors control probability by administering ablative doses without an increased toxicity. Considering the rising number of positive clinical experiences, the objective of this work is to evaluate LRT safety and efficacy. Method: Reports about LRT clinical experience were identified with a systematic review conducted on four different databases (namely, Medline, Embase, Scopus, and Cochrane Library) through the August 2022. Only LRT clinical reports published in English and with the access to the full manuscript text were considered as eligible. The 2020 update version PRISMA statement was followed. Results: Data extraction was performed from 12 eligible records encompassing 7 case reports, 1 case series, and 4 clinical studies. 81 patients (84 lesions) with a large lesion ranging from 63.2 cc to 3713.5 cc were subjected to exclusive, hybrid, and metabolism guided LRT. Excluding two very severe toxicity with a questionable relation with LRT, available clinical experience seem to confirm LRT safety. When a complete response was not achieved 3–6 months after LRT, a median lesion reduction approximately ≥50 % was registered. Conclusion: This systematic review appear to suggest LRT safety, especially for exclusive LRT. The very low level of evidence and the studies heterogeneity preclude drawing definitive conclusions on LRT efficacy, even though an interesting trend in terms of lesions reduction has been described.http://www.sciencedirect.com/science/article/pii/S2405630822001276Lattice radiation therapyLattice radiotherapySpatially fractionated radiotherapyAbscopal effectBulkyRadiotherapy |
| spellingShingle | Federico Iori Anna Cappelli Elisa D'Angelo Salvatore Cozzi Sebastiano Finocchi Ghersi Francesca De Felice Patrizia Ciammella Alessio Bruni Cinzia Iotti Lattice Radiation Therapy in clinical practice: A systematic review Clinical and Translational Radiation Oncology Lattice radiation therapy Lattice radiotherapy Spatially fractionated radiotherapy Abscopal effect Bulky Radiotherapy |
| title | Lattice Radiation Therapy in clinical practice: A systematic review |
| title_full | Lattice Radiation Therapy in clinical practice: A systematic review |
| title_fullStr | Lattice Radiation Therapy in clinical practice: A systematic review |
| title_full_unstemmed | Lattice Radiation Therapy in clinical practice: A systematic review |
| title_short | Lattice Radiation Therapy in clinical practice: A systematic review |
| title_sort | lattice radiation therapy in clinical practice a systematic review |
| topic | Lattice radiation therapy Lattice radiotherapy Spatially fractionated radiotherapy Abscopal effect Bulky Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405630822001276 |
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