High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension
Background and ObjectiveThe association between plasma betaine levels and cardiovascular diseases (CVDs) has been revealed except for pulmonary hypertension (PH). In this study, we aimed to explore the role of betaine in patients with PH.MethodsInpatients with PH at Fuwai Hospital were enrolled afte...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.852009/full |
| _version_ | 1818287292619423744 |
|---|---|
| author | Yicheng Yang Jing Xu Jingjing Zhou Jing Xue Jianing Gao Xin Li Bo Sun Beilan Yang Zhihong Liu Zhihui Zhao Qin Luo Qixian Zeng Lemin Zheng Lemin Zheng Changming Xiong |
| author_facet | Yicheng Yang Jing Xu Jingjing Zhou Jing Xue Jianing Gao Xin Li Bo Sun Beilan Yang Zhihong Liu Zhihui Zhao Qin Luo Qixian Zeng Lemin Zheng Lemin Zheng Changming Xiong |
| author_sort | Yicheng Yang |
| collection | DOAJ |
| description | Background and ObjectiveThe association between plasma betaine levels and cardiovascular diseases (CVDs) has been revealed except for pulmonary hypertension (PH). In this study, we aimed to explore the role of betaine in patients with PH.MethodsInpatients with PH at Fuwai Hospital were enrolled after excluding relative comorbidities. Each patient received at least one follow-up through a clinical visit, and the fasting blood was obtained both at the first and second hospitalization for betaine detection. The primary endpoint was defined as composite outcome events and the mean duration was 14.3 (6.9, 21.3) months. The associations of betaine and changes of betaine (Δbetaine) with disease severity and prognosis were explored.ResultsFinally, a total of 216 patients with PH were included and the medians for betaine plasma levels in the total patients group, low betaine, and high betaine groups were 49.8 (39.0, 68.3) μM, 39.0 (33.5, 44.7) μM, and 68.1 (57.8, 88.7) μM, respectively. High betaine was associated with poor World Health Organization Functional Class (WHO-FC), increased N-terminal pro-brain natriuretic peptide (NT-proBNP), low tricuspid annular plane systolic excursion (TAPSE), and cardiac output index even after adjusting for confounders. Patients with high betaine were over twice the risk to receive the poor prognosis than those with a low level [hazard ratio (HR) = 2.080, (95% CI: 1.033–4.188)]. Moreover, the decrease of betaine level after further treatment was positively correlated to ΔNT-proBNP indicating Δbetaine might be an effector of disease severity, and dynamic increase of betaine was also associated with poor prognosis in PH.ConclusionBetaine was associated with disease severity and might be an effector in PH. Patients with increased levels or with dynamic rise of betaine heralded a poor prognosis. |
| first_indexed | 2024-12-13T01:38:10Z |
| format | Article |
| id | doaj.art-86d6b755b6894ee1af174b650a640d0f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-13T01:38:10Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-86d6b755b6894ee1af174b650a640d0f2022-12-22T00:03:50ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-03-01910.3389/fcvm.2022.852009852009High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary HypertensionYicheng Yang0Jing Xu1Jingjing Zhou2Jing Xue3Jianing Gao4Xin Li5Bo Sun6Beilan Yang7Zhihong Liu8Zhihui Zhao9Qin Luo10Qixian Zeng11Lemin Zheng12Lemin Zheng13Changming Xiong14Center of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, Beijing, ChinaThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Health Science Center, Peking University, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Information Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, Beijing, ChinaThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Health Science Center, Peking University, Beijing, ChinaCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBackground and ObjectiveThe association between plasma betaine levels and cardiovascular diseases (CVDs) has been revealed except for pulmonary hypertension (PH). In this study, we aimed to explore the role of betaine in patients with PH.MethodsInpatients with PH at Fuwai Hospital were enrolled after excluding relative comorbidities. Each patient received at least one follow-up through a clinical visit, and the fasting blood was obtained both at the first and second hospitalization for betaine detection. The primary endpoint was defined as composite outcome events and the mean duration was 14.3 (6.9, 21.3) months. The associations of betaine and changes of betaine (Δbetaine) with disease severity and prognosis were explored.ResultsFinally, a total of 216 patients with PH were included and the medians for betaine plasma levels in the total patients group, low betaine, and high betaine groups were 49.8 (39.0, 68.3) μM, 39.0 (33.5, 44.7) μM, and 68.1 (57.8, 88.7) μM, respectively. High betaine was associated with poor World Health Organization Functional Class (WHO-FC), increased N-terminal pro-brain natriuretic peptide (NT-proBNP), low tricuspid annular plane systolic excursion (TAPSE), and cardiac output index even after adjusting for confounders. Patients with high betaine were over twice the risk to receive the poor prognosis than those with a low level [hazard ratio (HR) = 2.080, (95% CI: 1.033–4.188)]. Moreover, the decrease of betaine level after further treatment was positively correlated to ΔNT-proBNP indicating Δbetaine might be an effector of disease severity, and dynamic increase of betaine was also associated with poor prognosis in PH.ConclusionBetaine was associated with disease severity and might be an effector in PH. Patients with increased levels or with dynamic rise of betaine heralded a poor prognosis.https://www.frontiersin.org/articles/10.3389/fcvm.2022.852009/fullmetabolitesbetainepulmonary hypertensionseverityprognosisΔbetaine |
| spellingShingle | Yicheng Yang Jing Xu Jingjing Zhou Jing Xue Jianing Gao Xin Li Bo Sun Beilan Yang Zhihong Liu Zhihui Zhao Qin Luo Qixian Zeng Lemin Zheng Lemin Zheng Changming Xiong High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension Frontiers in Cardiovascular Medicine metabolites betaine pulmonary hypertension severity prognosis Δbetaine |
| title | High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension |
| title_full | High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension |
| title_fullStr | High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension |
| title_full_unstemmed | High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension |
| title_short | High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension |
| title_sort | high betaine and dynamic increase of betaine levels are both associated with poor prognosis of patients with pulmonary hypertension |
| topic | metabolites betaine pulmonary hypertension severity prognosis Δbetaine |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.852009/full |
| work_keys_str_mv | AT yichengyang highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT jingxu highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT jingjingzhou highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT jingxue highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT jianinggao highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT xinli highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT bosun highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT beilanyang highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT zhihongliu highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT zhihuizhao highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT qinluo highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT qixianzeng highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT leminzheng highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT leminzheng highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension AT changmingxiong highbetaineanddynamicincreaseofbetainelevelsarebothassociatedwithpoorprognosisofpatientswithpulmonaryhypertension |