The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury

The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury

Abstract The enzyme arginase 1 (A1) hydrolyzes the amino acid arginine to form L-ornithine and urea. Ornithine is further converted to polyamines by the ornithine decarboxylase (ODC) enzyme. We previously reported that deletion of myeloid A1 in mice exacerbates retinal damage after ischemia/reperfus...

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Bibliographic Details
Main Authors: Esraa Shosha, Rami A. Shahror, Carol A. Morris, Zhimin Xu, Rudolf Lucas, Meghan E. McGee-Lawrence, Nancy J. Rusch, Ruth B. Caldwell, Abdelrahman Y. Fouda
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06147-7

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