Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28

Let-7a suppresses Ewing sarcoma CSCs’ malignant phenotype via forming a positive feedback circuit with STAT3 and lin28

Cancer stem cells (CSCs) have been documented to be closely related with tumor metastasis and recurrence, and the same important role were identified in Ewing Sarcoma (ES). In our previous study, we found that let-7a expression was repressed in ES. Herein, we further identified its putative effects...

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Bibliographic Details
Main Authors: Jiang Xu, Zhongzu Zhang, Lu Huang, Jiachao Xiong, Zhenhai Zhou, Honggui Yu, Liang Wu, Zhimin Liu, Kai Cao
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Bone Oncology
Subjects:
Ewing sarcoma
Cancer stem cells
Let-7a
STAT3
Lin28
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137421000610

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