Antibody-based soluble and membrane-bound TWEAK mimicking agonists with FcγR-independent activity

Antibody-based soluble and membrane-bound TWEAK mimicking agonists with FcγR-independent activity

Fibroblast growth factor (FGF)-inducible 14 (Fn14) activates the classical and alternative NFκB (nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells) signaling pathway but also enhances tumor necrosis factor (TNF)-induced cell death. Fn14 expression is upregulated in non-hematopoietic c...

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Bibliographic Details
Main Authors: Olena Zaitseva, Annett Hoffmann, Margaretha Löst, Mohamed A. Anany, Tengyu Zhang, Kirstin Kucka, Armin Wiegering, Christoph Otto, Harald Wajant
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
agonistic antibodies
cell death
FcγR
Fn14
NFκB
TNF receptor superfamily
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194610/full

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