Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing
The treatment of urinary tract infections is usually empirical. For example, nitrofuran derivatives, mainly nitrofurantoin (but also furazidin), are used in Eastern Europe. A significant problem is the assessment of the usefulness of furazidin, as there are no standards for susceptibility testing. A...
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/16/5166 |
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| author | Filip Bielec Małgorzata Brauncajs Dorota Pastuszak-Lewandoska |
| author_facet | Filip Bielec Małgorzata Brauncajs Dorota Pastuszak-Lewandoska |
| author_sort | Filip Bielec |
| collection | DOAJ |
| description | The treatment of urinary tract infections is usually empirical. For example, nitrofuran derivatives, mainly nitrofurantoin (but also furazidin), are used in Eastern Europe. A significant problem is the assessment of the usefulness of furazidin, as there are no standards for susceptibility testing. Additionally, a high percentage of strains resistant to nitrofurantoin should prompt caution when choosing furazidin in therapy. This study aimed to answer the question of whether it is possible to use nitrofurantoin susceptibility for furazidin drug susceptibility analyses and if there is any cross-resistance in the nitrofuran derivatives group. One hundred <i>E. coli</i> clinical isolates, obtained from the Central Teaching Hospital of the Medical University of Lodz, were cultured from positive urine samples. For susceptibility testing, microdilution and disk diffusion methods, following EUCAST guidelines, were used. The results showed that the MICs of furazidin were equal to or lower than those of nitrofurantoin in 89% of the tested strains. The MIC<sub>50/90</sub> values for furazidin were two times lower than those for nitrofurantoin. Positive correlations were found between MICs and growth inhibition zones for both antibiotics. Based on the obtained data and previous studies, it was assumed that the transfer of susceptibility testing results from nitrofurantoin to furazidin is acceptable due to cross-resistance in nitrofuran derivatives. |
| first_indexed | 2024-03-10T23:51:33Z |
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| id | doaj.art-86daebb3fc60431280fa579898922700 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:51:33Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-86daebb3fc60431280fa5798989227002023-11-19T01:38:42ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011216516610.3390/jcm12165166Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility TestingFilip Bielec0Małgorzata Brauncajs1Dorota Pastuszak-Lewandoska2Department of Microbiology and Laboratory Medical Immunology, Medical University of Lodz, 90-151 Lodz, PolandDepartment of Microbiology and Laboratory Medical Immunology, Medical University of Lodz, 90-151 Lodz, PolandDepartment of Microbiology and Laboratory Medical Immunology, Medical University of Lodz, 90-151 Lodz, PolandThe treatment of urinary tract infections is usually empirical. For example, nitrofuran derivatives, mainly nitrofurantoin (but also furazidin), are used in Eastern Europe. A significant problem is the assessment of the usefulness of furazidin, as there are no standards for susceptibility testing. Additionally, a high percentage of strains resistant to nitrofurantoin should prompt caution when choosing furazidin in therapy. This study aimed to answer the question of whether it is possible to use nitrofurantoin susceptibility for furazidin drug susceptibility analyses and if there is any cross-resistance in the nitrofuran derivatives group. One hundred <i>E. coli</i> clinical isolates, obtained from the Central Teaching Hospital of the Medical University of Lodz, were cultured from positive urine samples. For susceptibility testing, microdilution and disk diffusion methods, following EUCAST guidelines, were used. The results showed that the MICs of furazidin were equal to or lower than those of nitrofurantoin in 89% of the tested strains. The MIC<sub>50/90</sub> values for furazidin were two times lower than those for nitrofurantoin. Positive correlations were found between MICs and growth inhibition zones for both antibiotics. Based on the obtained data and previous studies, it was assumed that the transfer of susceptibility testing results from nitrofurantoin to furazidin is acceptable due to cross-resistance in nitrofuran derivatives.https://www.mdpi.com/2077-0383/12/16/5166nitrofuran derivativescross-resistanceurinary tract infection<i>Escherichia coli</i>nitrofurantoinfurazidin |
| spellingShingle | Filip Bielec Małgorzata Brauncajs Dorota Pastuszak-Lewandoska Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing Journal of Clinical Medicine nitrofuran derivatives cross-resistance urinary tract infection <i>Escherichia coli</i> nitrofurantoin furazidin |
| title | Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing |
| title_full | Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing |
| title_fullStr | Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing |
| title_full_unstemmed | Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing |
| title_short | Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic <i>Escherichia coli</i> Nitrofurantoin and Furazidin In Vitro Susceptibility Testing |
| title_sort | nitrofuran derivatives cross resistance evidence uropathogenic i escherichia coli i nitrofurantoin and furazidin in vitro susceptibility testing |
| topic | nitrofuran derivatives cross-resistance urinary tract infection <i>Escherichia coli</i> nitrofurantoin furazidin |
| url | https://www.mdpi.com/2077-0383/12/16/5166 |
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