Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model

Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model

A limitation for recombinant adeno-associated virus (rAAV)-mediated gene transfer into the central nervous system (CNS) is the low penetration of vectors across the human blood-brain barrier (BBB). High doses of intravenously delivered vector are required to reach the CNS, which has resulted in vary...

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Bibliographic Details
Main Authors: Ren Song, Katja Pekrun, Themasap A. Khan, Feijie Zhang, Sergiu P. Paşca, Mark A. Kay
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
blood brain barrier
CNS capsids
transwell
human BBB
central nervous system
chimeric AAV vectors
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001279

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