ALKBH5-mediated m6A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression

ALKBH5-mediated m6A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression

Summary: HS3ST3B1-IT1 was identified as a downregulated long noncoding RNA in osteoarthritic cartilage. However, its roles and mechanisms in the pathogenesis of osteoarthritis (OA) are unclear. In this study, we demonstrated that the expressions of HS3ST3B1-IT1 and its maternal gene HS3ST3B1 were do...

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Bibliographic Details
Main Authors: Yuting Tang, Yang Liu, Xiaoshu Zhu, Yanlin Chen, Xinluan Jiang, Siyang Ding, Que Zheng, Ming Zhang, Jiashu Yang, Yunfei Ma, Mengying Xing, Zongyu Zhang, Huimin Ding, Yucui Jin, Changyan Ma
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Orthopedics
Biological sciences
Molecular biology
Molecular mechanism of gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223019156

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