Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity
A response surface methodology was applied to optimize the variables affecting the supercritical fluid carbon dioxide extraction of oil from the fruit of Gardenia jasminoides using the Box–Behnken design. The optimum extraction parameters were an extraction temperature of 49.94 °C, an extraction pres...
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MDPI AG
2014-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/12/19350 |
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| author | Weiwei Tao Hailou Zhang Wenda Xue Li Ren Baomei Xia Xin Zhou Haoxin Wu Jinao Duan Gang Chen |
| author_facet | Weiwei Tao Hailou Zhang Wenda Xue Li Ren Baomei Xia Xin Zhou Haoxin Wu Jinao Duan Gang Chen |
| author_sort | Weiwei Tao |
| collection | DOAJ |
| description | A response surface methodology was applied to optimize the variables affecting the supercritical fluid carbon dioxide extraction of oil from the fruit of Gardenia jasminoides using the Box–Behnken design. The optimum extraction parameters were an extraction temperature of 49.94 °C, an extraction pressure of 29.89 MPa and an extraction time of 93.82 min. Through a GC/MS analysis, we revealed 16 major components of the oil extract, which showed potent antidepressant effects in both of two behavior despair models in mice: tail suspension test and forced swimming test. Our results suggest that the oil extract of Gardenia jasminoides prepared using the supercritical fluid carbon dioxide extraction may contain effective constituents to be used for depression therapy. |
| first_indexed | 2024-12-23T23:11:34Z |
| format | Article |
| id | doaj.art-86dc526ec89b4d0fb5d883e065a1c25d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T23:11:34Z |
| publishDate | 2014-11-01 |
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| series | Molecules |
| spelling | doaj.art-86dc526ec89b4d0fb5d883e065a1c25d2022-12-21T17:26:39ZengMDPI AGMolecules1420-30492014-11-011912193501936010.3390/molecules191219350molecules191219350Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant ActivityWeiwei Tao0Hailou Zhang1Wenda Xue2Li Ren3Baomei Xia4Xin Zhou5Haoxin Wu6Jinao Duan7Gang Chen8Center for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaNational and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCenter for Translational Systems Biology and Neuroscience, School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaA response surface methodology was applied to optimize the variables affecting the supercritical fluid carbon dioxide extraction of oil from the fruit of Gardenia jasminoides using the Box–Behnken design. The optimum extraction parameters were an extraction temperature of 49.94 °C, an extraction pressure of 29.89 MPa and an extraction time of 93.82 min. Through a GC/MS analysis, we revealed 16 major components of the oil extract, which showed potent antidepressant effects in both of two behavior despair models in mice: tail suspension test and forced swimming test. Our results suggest that the oil extract of Gardenia jasminoides prepared using the supercritical fluid carbon dioxide extraction may contain effective constituents to be used for depression therapy.http://www.mdpi.com/1420-3049/19/12/19350supercritical fluid extractionresponse surface methodologyoilGardenia jasminoidesantidepressant effect |
| spellingShingle | Weiwei Tao Hailou Zhang Wenda Xue Li Ren Baomei Xia Xin Zhou Haoxin Wu Jinao Duan Gang Chen Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity Molecules supercritical fluid extraction response surface methodology oil Gardenia jasminoides antidepressant effect |
| title | Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity |
| title_full | Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity |
| title_fullStr | Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity |
| title_full_unstemmed | Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity |
| title_short | Optimization of Supercritical Fluid Extraction of Oil from the Fruit of Gardenia jasminoides and Its Antidepressant Activity |
| title_sort | optimization of supercritical fluid extraction of oil from the fruit of gardenia jasminoides and its antidepressant activity |
| topic | supercritical fluid extraction response surface methodology oil Gardenia jasminoides antidepressant effect |
| url | http://www.mdpi.com/1420-3049/19/12/19350 |
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