Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province
Introduction: Klebsiella pneumoniae is one of Klebsiella species. K. pneumoniae is one of the most important bacteria causing nosocomial infections. This bacterium threatens public health and leads to increased hospital costs and mortality rate. The purpose of this study was to determine the pattern...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Islamic Azad University
2015-03-01
|
| Series: | Report of Health Care |
| Subjects: | |
| Online Access: | http://jrhc.miau.ac.ir/article_2634_97bdfcaef42aed2905eda9ca159fa4f3.pdf |
| _version_ | 1818109083341815808 |
|---|---|
| author | Sajad Babakhani Shahram Shokri Mahdieh Baharvand |
| author_facet | Sajad Babakhani Shahram Shokri Mahdieh Baharvand |
| author_sort | Sajad Babakhani |
| collection | DOAJ |
| description | Introduction: Klebsiella pneumoniae is one of Klebsiella species. K. pneumoniae is one of the most important bacteria causing nosocomial infections. This bacterium threatens public health and leads to increased hospital costs and mortality rate. The purpose of this study was to determine the pattern of antibiotic resistance in K. pneumoniae in nosocomial infections.<br />Methods: This study was performed on 51 samples of Klebsiella isolates from 500 patients in three units of Aleshtar hospital in 9 months. The antibiotic resistance of K. pneumoniae to 18 antibiotics was performed by Kirby Bauer disk diffusion method.<br />Results: The frequency of K. pneumonia among 500 samples was determined 51 cases (10.2%). The largest number of K. pneumoniae was isolated from the infectious unit (49.02%). The frequency of K. pneumoniae based on the source of infection for urine was 22 cases (43.14%), sputum 17 (33.33%), stool 6 (11.77%), wound 4 (7.84%), blood 2 (3.92%), and cerebrospinal fluid 0 (0%), respectively. K. pneumoniae resistance to antibiotics included: ceftriaxone (94.12%), ciprofloxacin (90.20%), ofloxacin (86.27%), cefotaxime (78.43%), nalidixic acid (58.82%), nitrofurantoin (56.86%), aztreonam (54.90%), ampicillin/sulbactam (50.98% ), ticarcillin (45.09%), cefepime (43.14%), colistin (43.14%), gentamicin (41.18%), azithromycin (41.18%), polymyxin B (39.22%), piperacillin/tazobactam (19.61%), amikacin ( 15.69%), imipenem (5.88%), and meropenem (3.92%).<br />Conclusion: Meropenem and imipenem with the lowest resistance were the most effective antibiotics against K .pneumoniae. Ceftriaxone, and ciprofloxacin antibiotic had the lowest effect on the treatment of K. pneumoniae. |
| first_indexed | 2024-12-11T02:25:37Z |
| format | Article |
| id | doaj.art-86dc7d0429064123b4893cbb6b126931 |
| institution | Directory Open Access Journal |
| issn | 2423-4141 2423-4141 |
| language | English |
| last_indexed | 2024-12-11T02:25:37Z |
| publishDate | 2015-03-01 |
| publisher | Islamic Azad University |
| record_format | Article |
| series | Report of Health Care |
| spelling | doaj.art-86dc7d0429064123b4893cbb6b1269312022-12-22T01:23:56ZengIslamic Azad UniversityReport of Health Care2423-41412423-41412015-03-011255592634Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan provinceSajad Babakhani0Shahram Shokri1Mahdieh Baharvand2MSc of Microbiology, Department of Biology, Islamic Azad University, Ashkezar Branch, Ashkezar, IranAssistant Professor, Infectious Diseases Specialist, Lorestan University of Medical Sciences, Khorramabad, IranMSc of Microbiology, Department of Biology, Islamic Azad University, Borujerd Branch, Borujerd, IranIntroduction: Klebsiella pneumoniae is one of Klebsiella species. K. pneumoniae is one of the most important bacteria causing nosocomial infections. This bacterium threatens public health and leads to increased hospital costs and mortality rate. The purpose of this study was to determine the pattern of antibiotic resistance in K. pneumoniae in nosocomial infections.<br />Methods: This study was performed on 51 samples of Klebsiella isolates from 500 patients in three units of Aleshtar hospital in 9 months. The antibiotic resistance of K. pneumoniae to 18 antibiotics was performed by Kirby Bauer disk diffusion method.<br />Results: The frequency of K. pneumonia among 500 samples was determined 51 cases (10.2%). The largest number of K. pneumoniae was isolated from the infectious unit (49.02%). The frequency of K. pneumoniae based on the source of infection for urine was 22 cases (43.14%), sputum 17 (33.33%), stool 6 (11.77%), wound 4 (7.84%), blood 2 (3.92%), and cerebrospinal fluid 0 (0%), respectively. K. pneumoniae resistance to antibiotics included: ceftriaxone (94.12%), ciprofloxacin (90.20%), ofloxacin (86.27%), cefotaxime (78.43%), nalidixic acid (58.82%), nitrofurantoin (56.86%), aztreonam (54.90%), ampicillin/sulbactam (50.98% ), ticarcillin (45.09%), cefepime (43.14%), colistin (43.14%), gentamicin (41.18%), azithromycin (41.18%), polymyxin B (39.22%), piperacillin/tazobactam (19.61%), amikacin ( 15.69%), imipenem (5.88%), and meropenem (3.92%).<br />Conclusion: Meropenem and imipenem with the lowest resistance were the most effective antibiotics against K .pneumoniae. Ceftriaxone, and ciprofloxacin antibiotic had the lowest effect on the treatment of K. pneumoniae.http://jrhc.miau.ac.ir/article_2634_97bdfcaef42aed2905eda9ca159fa4f3.pdfKlebsiella pneumoniaeAntibiotic resistanceNosocomial infections |
| spellingShingle | Sajad Babakhani Shahram Shokri Mahdieh Baharvand Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province Report of Health Care Klebsiella pneumoniae Antibiotic resistance Nosocomial infections |
| title | Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province |
| title_full | Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province |
| title_fullStr | Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province |
| title_full_unstemmed | Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province |
| title_short | Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province |
| title_sort | antibiotic resistance pattern of klebsiella pneumoniae isolated from nosocomial infections in aleshtar hospital lorestan province |
| topic | Klebsiella pneumoniae Antibiotic resistance Nosocomial infections |
| url | http://jrhc.miau.ac.ir/article_2634_97bdfcaef42aed2905eda9ca159fa4f3.pdf |
| work_keys_str_mv | AT sajadbabakhani antibioticresistancepatternofklebsiellapneumoniaeisolatedfromnosocomialinfectionsinaleshtarhospitallorestanprovince AT shahramshokri antibioticresistancepatternofklebsiellapneumoniaeisolatedfromnosocomialinfectionsinaleshtarhospitallorestanprovince AT mahdiehbaharvand antibioticresistancepatternofklebsiellapneumoniaeisolatedfromnosocomialinfectionsinaleshtarhospitallorestanprovince |