Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers
(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/18/4549 |
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| author | Tamer Soror Justina Paul Corinna Melchert Christian Idel Dirk Rades Karl-Ludwig Bruchhage György Kovács Anke Leichtle |
| author_facet | Tamer Soror Justina Paul Corinna Melchert Christian Idel Dirk Rades Karl-Ludwig Bruchhage György Kovács Anke Leichtle |
| author_sort | Tamer Soror |
| collection | DOAJ |
| description | (1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities. |
| first_indexed | 2024-03-10T22:57:24Z |
| format | Article |
| id | doaj.art-86dcb68373ec43ac9f5e1acfc969151c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T22:57:24Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-86dcb68373ec43ac9f5e1acfc969151c2023-11-19T09:55:22ZengMDPI AGCancers2072-66942023-09-011518454910.3390/cancers15184549Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck CancersTamer Soror0Justina Paul1Corinna Melchert2Christian Idel3Dirk Rades4Karl-Ludwig Bruchhage5György Kovács6Anke Leichtle7Radiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, GermanyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, GermanyRadiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, GermanyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, GermanyRadiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, GermanyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, GermanyUniversità Cattolica del Sacro Cuore, Gemelli-INTERACTS, 00168 Rome, ItalyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, Germany(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities.https://www.mdpi.com/2072-6694/15/18/4549interventional radiotherapyhigh-dose-rate brachytherapyhead and neck cancerlocal recurrence |
| spellingShingle | Tamer Soror Justina Paul Corinna Melchert Christian Idel Dirk Rades Karl-Ludwig Bruchhage György Kovács Anke Leichtle Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers Cancers interventional radiotherapy high-dose-rate brachytherapy head and neck cancer local recurrence |
| title | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
| title_full | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
| title_fullStr | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
| title_full_unstemmed | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
| title_short | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
| title_sort | salvage high dose rate interventional radiotherapy brachytherapy combined with surgery for regionally relapsed head and neck cancers |
| topic | interventional radiotherapy high-dose-rate brachytherapy head and neck cancer local recurrence |
| url | https://www.mdpi.com/2072-6694/15/18/4549 |
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