Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers
(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head a...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-09-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/15/18/4549 |
_version_ | 1797580884795195392 |
---|---|
author | Tamer Soror Justina Paul Corinna Melchert Christian Idel Dirk Rades Karl-Ludwig Bruchhage György Kovács Anke Leichtle |
author_facet | Tamer Soror Justina Paul Corinna Melchert Christian Idel Dirk Rades Karl-Ludwig Bruchhage György Kovács Anke Leichtle |
author_sort | Tamer Soror |
collection | DOAJ |
description | (1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities. |
first_indexed | 2024-03-10T22:57:24Z |
format | Article |
id | doaj.art-86dcb68373ec43ac9f5e1acfc969151c |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T22:57:24Z |
publishDate | 2023-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-86dcb68373ec43ac9f5e1acfc969151c2023-11-19T09:55:22ZengMDPI AGCancers2072-66942023-09-011518454910.3390/cancers15184549Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck CancersTamer Soror0Justina Paul1Corinna Melchert2Christian Idel3Dirk Rades4Karl-Ludwig Bruchhage5György Kovács6Anke Leichtle7Radiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, GermanyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, GermanyRadiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, GermanyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, GermanyRadiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, GermanyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, GermanyUniversità Cattolica del Sacro Cuore, Gemelli-INTERACTS, 00168 Rome, ItalyDepartment of Oto-Rhino-Laryngology and Head and Neck Surgery, University of Lübeck, 23562 Lübeck, Germany(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities.https://www.mdpi.com/2072-6694/15/18/4549interventional radiotherapyhigh-dose-rate brachytherapyhead and neck cancerlocal recurrence |
spellingShingle | Tamer Soror Justina Paul Corinna Melchert Christian Idel Dirk Rades Karl-Ludwig Bruchhage György Kovács Anke Leichtle Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers Cancers interventional radiotherapy high-dose-rate brachytherapy head and neck cancer local recurrence |
title | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
title_full | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
title_fullStr | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
title_full_unstemmed | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
title_short | Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers |
title_sort | salvage high dose rate interventional radiotherapy brachytherapy combined with surgery for regionally relapsed head and neck cancers |
topic | interventional radiotherapy high-dose-rate brachytherapy head and neck cancer local recurrence |
url | https://www.mdpi.com/2072-6694/15/18/4549 |
work_keys_str_mv | AT tamersoror salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT justinapaul salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT corinnamelchert salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT christianidel salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT dirkrades salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT karlludwigbruchhage salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT gyorgykovacs salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers AT ankeleichtle salvagehighdoserateinterventionalradiotherapybrachytherapycombinedwithsurgeryforregionallyrelapsedheadandneckcancers |