Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report
<p>Abstract</p> <p>Introduction</p> <p>Cryptococcal infections pose a diagnostic challenge in an immunocompetent host. Asbestos exposure has been associated with pulmonary aspergillosis. This case highlights an interesting presentation of cryptococcal lung inflammation...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-06-01
|
| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://www.jmedicalcasereports.com/content/6/1/170 |
| _version_ | 1818213615882207232 |
|---|---|
| author | Guy Judah P Raza Shahzad Bondi Elliot Rosen Yale Kim Dong-Sung Berger Barbara J |
| author_facet | Guy Judah P Raza Shahzad Bondi Elliot Rosen Yale Kim Dong-Sung Berger Barbara J |
| author_sort | Guy Judah P |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Cryptococcal infections pose a diagnostic challenge in an immunocompetent host. Asbestos exposure has been associated with pulmonary aspergillosis. This case highlights an interesting presentation of cryptococcal lung inflammation with underlying asbestosis.</p> <p>Case presentation</p> <p>A 63-year-old Mediterranean Caucasian woman presented with progressive dry cough of nine months duration. A computed tomography (CT) scan of her chest revealed multiple foci in the right infra-hilar region, which were seen as hot lung masses on a positron emission tomography (PET) scan. These multiple foci appeared metastatic in nature throughout both lung fields with early mediastinal invasion. A computed tomography (CT)-guided core biopsy was obtained from a dominant right lower lobe lung mass. Histology showed chronic granulomatous inflammation with numerous budding yeast forms that were GMS-, PAS-, and mucin-positive, consistent with cryptococcosis together with asbestos bodies (ferruginous). She was managed with fluconazole (400mg (6mg/kg) per day orally) daily. At her six-month follow up, she had marked improvement in her general condition along with a diminution of the lower lobe lung mass.</p> <p>Conclusion</p> <p>We report a clinical and radiological improvement in a patient treated for cryptococcal pneumonia. Asbestos exposure was likely to have been an important pathophysiological precursor to infection by environmental fungi.</p> |
| first_indexed | 2024-12-12T06:07:07Z |
| format | Article |
| id | doaj.art-86e0308110a04872ae90753ee5086de4 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-12T06:07:07Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-86e0308110a04872ae90753ee5086de42022-12-22T00:35:16ZengBMCJournal of Medical Case Reports1752-19472012-06-016117010.1186/1752-1947-6-170Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case reportGuy Judah PRaza ShahzadBondi ElliotRosen YaleKim Dong-SungBerger Barbara J<p>Abstract</p> <p>Introduction</p> <p>Cryptococcal infections pose a diagnostic challenge in an immunocompetent host. Asbestos exposure has been associated with pulmonary aspergillosis. This case highlights an interesting presentation of cryptococcal lung inflammation with underlying asbestosis.</p> <p>Case presentation</p> <p>A 63-year-old Mediterranean Caucasian woman presented with progressive dry cough of nine months duration. A computed tomography (CT) scan of her chest revealed multiple foci in the right infra-hilar region, which were seen as hot lung masses on a positron emission tomography (PET) scan. These multiple foci appeared metastatic in nature throughout both lung fields with early mediastinal invasion. A computed tomography (CT)-guided core biopsy was obtained from a dominant right lower lobe lung mass. Histology showed chronic granulomatous inflammation with numerous budding yeast forms that were GMS-, PAS-, and mucin-positive, consistent with cryptococcosis together with asbestos bodies (ferruginous). She was managed with fluconazole (400mg (6mg/kg) per day orally) daily. At her six-month follow up, she had marked improvement in her general condition along with a diminution of the lower lobe lung mass.</p> <p>Conclusion</p> <p>We report a clinical and radiological improvement in a patient treated for cryptococcal pneumonia. Asbestos exposure was likely to have been an important pathophysiological precursor to infection by environmental fungi.</p>http://www.jmedicalcasereports.com/content/6/1/170CryptococciAsbestosFluconazoleFerruginous bodiesMycobacterium tuberculosis |
| spellingShingle | Guy Judah P Raza Shahzad Bondi Elliot Rosen Yale Kim Dong-Sung Berger Barbara J Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report Journal of Medical Case Reports Cryptococci Asbestos Fluconazole Ferruginous bodies Mycobacterium tuberculosis |
| title | Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report |
| title_full | Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report |
| title_fullStr | Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report |
| title_full_unstemmed | Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report |
| title_short | Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report |
| title_sort | cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis a case report |
| topic | Cryptococci Asbestos Fluconazole Ferruginous bodies Mycobacterium tuberculosis |
| url | http://www.jmedicalcasereports.com/content/6/1/170 |
| work_keys_str_mv | AT guyjudahp cryptococcuspneumoniapresentinginanimmunocompetenthostwithpulmonaryasbestosisacasereport AT razashahzad cryptococcuspneumoniapresentinginanimmunocompetenthostwithpulmonaryasbestosisacasereport AT bondielliot cryptococcuspneumoniapresentinginanimmunocompetenthostwithpulmonaryasbestosisacasereport AT rosenyale cryptococcuspneumoniapresentinginanimmunocompetenthostwithpulmonaryasbestosisacasereport AT kimdongsung cryptococcuspneumoniapresentinginanimmunocompetenthostwithpulmonaryasbestosisacasereport AT bergerbarbaraj cryptococcuspneumoniapresentinginanimmunocompetenthostwithpulmonaryasbestosisacasereport |