The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men
We investigated the performance characteristics of prostate-specific antigen (PSA) and PSA density (PSAD) in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PB) from year 2000 to 2013 were included. The receiver operating characteristic (ROC) curves for...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=113;epage=116;aulast=Teoh |
| _version_ | 1818355615174492160 |
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| author | Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu |
| author_facet | Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu |
| author_sort | Jeremy YC Teoh |
| collection | DOAJ |
| description | We investigated the performance characteristics of prostate-specific antigen (PSA) and PSA density (PSAD) in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PB) from year 2000 to 2013 were included. The receiver operating characteristic (ROC) curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA (P < 0.001) and 0.823 for PSAD (P < 0.001). PSA of 4.5 ng ml−1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml−1 cc−1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml−1 (OR 1.61, 95% CI 1.05-2.45, P= 0.029) and PSAD cut-off at 0.12 ng ml−1 cc−1 (OR 6.22, 95% CI 4.20-9.22, P< 0.001) were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml−1 and PSAD of 0.12 ng ml−1 cc−1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men. |
| first_indexed | 2024-12-13T19:44:08Z |
| format | Article |
| id | doaj.art-86e1c766ecee424d841ea3f3214ca15c |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-13T19:44:08Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-86e1c766ecee424d841ea3f3214ca15c2022-12-21T23:33:37ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622017-01-0119111311610.4103/1008-682X.167103The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese menJeremy YC TeohSteffi KK YuenJames HL TsuCharles KW WongBrian SH HoAda TL NgWai-Kit MaKwan-Lun HoMing-Kwong YiuWe investigated the performance characteristics of prostate-specific antigen (PSA) and PSA density (PSAD) in Chinese men. All Chinese men who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PB) from year 2000 to 2013 were included. The receiver operating characteristic (ROC) curves for both PSA and PSAD were analyzed. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) at different cut-off levels were calculated. A total of 2606 Chinese men were included. For the ROC, the area under curve was 0.770 for PSA (P < 0.001) and 0.823 for PSAD (P < 0.001). PSA of 4.5 ng ml−1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml−1 cc−1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%. On multivariate logistic regression analyses, PSA cut-off at 4.5 ng ml−1 (OR 1.61, 95% CI 1.05-2.45, P= 0.029) and PSAD cut-off at 0.12 ng ml−1 cc−1 (OR 6.22, 95% CI 4.20-9.22, P< 0.001) were significant predictors for prostate cancer detection on TRUS-PB. In conclusion, the performances of PSA and PSAD at different cut-off levels in Chinese men were very different from those in Caucasians. PSA of 4.5 ng ml−1 and PSAD of 0.12 ng ml−1 cc−1 had near 95% sensitivity and were significant predictors of prostate cancer detection in Chinese men.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=113;epage=116;aulast=TeohChinese; prostate cancer; transrectal ultrasound-guided prostate biopsy; prostate-specific antigen; prostate-specific antigen density |
| spellingShingle | Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men Asian Journal of Andrology Chinese; prostate cancer; transrectal ultrasound-guided prostate biopsy; prostate-specific antigen; prostate-specific antigen density |
| title | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men |
| title_full | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men |
| title_fullStr | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men |
| title_full_unstemmed | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men |
| title_short | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men |
| title_sort | performance characteristics of prostate specific antigen and prostate specific antigen density in chinese men |
| topic | Chinese; prostate cancer; transrectal ultrasound-guided prostate biopsy; prostate-specific antigen; prostate-specific antigen density |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=1;spage=113;epage=116;aulast=Teoh |
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