Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp.
Flattening filter free (FFF) beams show the potential for a higher dose rate and lower peripheral dose. We investigated the planning study of FFF beams with their role for volumetric modulated arc therapy (VMAT) in squamous cell carcinoma of the scalp.One patient with squamous cell carcinoma which h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4266613?pdf=render |
| _version_ | 1818928751238447104 |
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| author | Youqun Lai Liwan Shi Qin Lin Lirong Fu Huiming Ha |
| author_facet | Youqun Lai Liwan Shi Qin Lin Lirong Fu Huiming Ha |
| author_sort | Youqun Lai |
| collection | DOAJ |
| description | Flattening filter free (FFF) beams show the potential for a higher dose rate and lower peripheral dose. We investigated the planning study of FFF beams with their role for volumetric modulated arc therapy (VMAT) in squamous cell carcinoma of the scalp.One patient with squamous cell carcinoma which had involvement of entire scalp was subjected to VMAT using TrueBeam linear accelerator. As it was a rare skin malignancy, CT data of 7 patients with brain tumors were also included in this study, and their entire scalps were outlined as target volumes. Three VMAT plans were employed with RapidArc form: two half-field full-arcs VMAT using 6 MV standard beams (HFF-VMAT-FF), eight half-field quarter-arcs VMAT using 6 MV standard beams (HFQ-VMAT-FF), and HFQ-VMAT using FFF beams (HFQ-VMAT-FFF). Prescribed dose was 25 × 2 Gy (50 Gy). Plan quality and efficiency were assessed for all plans.There were no statistically significant differences among the three VMAT plans in target volume coverage, conformity, and homogeneity. For HFQ-VMAT-FF plans, there was a significant decrease by 12.6% in the mean dose to the brain compared with HFF-VMAT-FF. By the use of FFF beams, the mean dose to brain in HFQ-VMAT-FFF plans was further decreased by 7.4% compared with HFQ-VMAT-FF. Beam delivery times were similar for each technique.The HFQ-VMAT-FF plans showed the superiority in dose distributions compared with HFF-VMAT-FF. HFQ-VMAT-FFF plans might provide further normal tissue sparing, particularly in the brain, showing their potential for radiation therapy in squamous cell carcinoma of the scalp. |
| first_indexed | 2024-12-20T03:33:53Z |
| format | Article |
| id | doaj.art-86e47429e80f4948b6cdeca2540d319b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T03:33:53Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-86e47429e80f4948b6cdeca2540d319b2022-12-21T19:54:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11495310.1371/journal.pone.0114953Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp.Youqun LaiLiwan ShiQin LinLirong FuHuiming HaFlattening filter free (FFF) beams show the potential for a higher dose rate and lower peripheral dose. We investigated the planning study of FFF beams with their role for volumetric modulated arc therapy (VMAT) in squamous cell carcinoma of the scalp.One patient with squamous cell carcinoma which had involvement of entire scalp was subjected to VMAT using TrueBeam linear accelerator. As it was a rare skin malignancy, CT data of 7 patients with brain tumors were also included in this study, and their entire scalps were outlined as target volumes. Three VMAT plans were employed with RapidArc form: two half-field full-arcs VMAT using 6 MV standard beams (HFF-VMAT-FF), eight half-field quarter-arcs VMAT using 6 MV standard beams (HFQ-VMAT-FF), and HFQ-VMAT using FFF beams (HFQ-VMAT-FFF). Prescribed dose was 25 × 2 Gy (50 Gy). Plan quality and efficiency were assessed for all plans.There were no statistically significant differences among the three VMAT plans in target volume coverage, conformity, and homogeneity. For HFQ-VMAT-FF plans, there was a significant decrease by 12.6% in the mean dose to the brain compared with HFF-VMAT-FF. By the use of FFF beams, the mean dose to brain in HFQ-VMAT-FFF plans was further decreased by 7.4% compared with HFQ-VMAT-FF. Beam delivery times were similar for each technique.The HFQ-VMAT-FF plans showed the superiority in dose distributions compared with HFF-VMAT-FF. HFQ-VMAT-FFF plans might provide further normal tissue sparing, particularly in the brain, showing their potential for radiation therapy in squamous cell carcinoma of the scalp.http://europepmc.org/articles/PMC4266613?pdf=render |
| spellingShingle | Youqun Lai Liwan Shi Qin Lin Lirong Fu Huiming Ha Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp. PLoS ONE |
| title | Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp. |
| title_full | Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp. |
| title_fullStr | Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp. |
| title_full_unstemmed | Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp. |
| title_short | Planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp. |
| title_sort | planning study of flattening filter free beams for volumetric modulated arc therapy in squamous cell carcinoma of the scalp |
| url | http://europepmc.org/articles/PMC4266613?pdf=render |
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