Cancer cells remodeling and quality control are inextricably linked to autophagy
Autophagy is a normal cellular physiological process. As one of the cell degradation systems, it participates in the lysosomal pathway process of degrading damaged proteins and subcellular organelles to maintain cell metabolism and energy states. Moreover, autophagy is essential for regulating organ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2023-06-01
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| Series: | AIMS Molecular Science |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2023009?viewType=HTML |
| _version_ | 1797688464951476224 |
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| author | Chunzheng Li Chenyu Wei Gongke Zhao Xianguang Yang |
| author_facet | Chunzheng Li Chenyu Wei Gongke Zhao Xianguang Yang |
| author_sort | Chunzheng Li |
| collection | DOAJ |
| description | Autophagy is a normal cellular physiological process. As one of the cell degradation systems, it participates in the lysosomal pathway process of degrading damaged proteins and subcellular organelles to maintain cell metabolism and energy states. Moreover, autophagy is essential for regulating organelle quality control and cell homeostasis. In recent decades, a large number of studies have demonstrated that autophagy abnormalities are present in a variety of human malignancies and that autophagy plays a crucial role in all stages of tumor development. Multiple tumors interfere with autophagy's normal regulation and use autophagy's essential properties to restructure their proteome, reprogram their metabolism, and adapt to stress. This article primarily discusses how autophagy either promotes or inhibits cancer development, the significance of autophagy in maintaining cell genome stability, and the role of selective autophagy in the reshaping and quality control of tumor cells. |
| first_indexed | 2024-03-12T01:31:22Z |
| format | Article |
| id | doaj.art-86e498ec23e4411db66f282dedde71d6 |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-03-12T01:31:22Z |
| publishDate | 2023-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-86e498ec23e4411db66f282dedde71d62023-09-12T01:27:05ZengAIMS PressAIMS Molecular Science2372-03012023-06-0110210912610.3934/molsci.2023009Cancer cells remodeling and quality control are inextricably linked to autophagyChunzheng Li0Chenyu Wei1Gongke Zhao2Xianguang Yang3College of Life science, Henan Normal University, Xinxiang 453003, Henan Province, ChinaCollege of Life science, Henan Normal University, Xinxiang 453003, Henan Province, ChinaCollege of Life science, Henan Normal University, Xinxiang 453003, Henan Province, ChinaCollege of Life science, Henan Normal University, Xinxiang 453003, Henan Province, ChinaAutophagy is a normal cellular physiological process. As one of the cell degradation systems, it participates in the lysosomal pathway process of degrading damaged proteins and subcellular organelles to maintain cell metabolism and energy states. Moreover, autophagy is essential for regulating organelle quality control and cell homeostasis. In recent decades, a large number of studies have demonstrated that autophagy abnormalities are present in a variety of human malignancies and that autophagy plays a crucial role in all stages of tumor development. Multiple tumors interfere with autophagy's normal regulation and use autophagy's essential properties to restructure their proteome, reprogram their metabolism, and adapt to stress. This article primarily discusses how autophagy either promotes or inhibits cancer development, the significance of autophagy in maintaining cell genome stability, and the role of selective autophagy in the reshaping and quality control of tumor cells.https://www.aimspress.com/article/doi/10.3934/molsci.2023009?viewType=HTMLautophagycancerquality controlremodelinggenomic stability |
| spellingShingle | Chunzheng Li Chenyu Wei Gongke Zhao Xianguang Yang Cancer cells remodeling and quality control are inextricably linked to autophagy AIMS Molecular Science autophagy cancer quality control remodeling genomic stability |
| title | Cancer cells remodeling and quality control are inextricably linked to autophagy |
| title_full | Cancer cells remodeling and quality control are inextricably linked to autophagy |
| title_fullStr | Cancer cells remodeling and quality control are inextricably linked to autophagy |
| title_full_unstemmed | Cancer cells remodeling and quality control are inextricably linked to autophagy |
| title_short | Cancer cells remodeling and quality control are inextricably linked to autophagy |
| title_sort | cancer cells remodeling and quality control are inextricably linked to autophagy |
| topic | autophagy cancer quality control remodeling genomic stability |
| url | https://www.aimspress.com/article/doi/10.3934/molsci.2023009?viewType=HTML |
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