Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity
<b>Background</b>: Women with gestational diabetes (GDM) have an increased risk of metabolic syndrome (MS) after delivery. MS could precede gravidity. The aims of this study were (i) to detect the prevalence of MS in women at the time of GDM diagnosis, (ii) to detect the prevalence of MS...
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1260 |
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| author | Vendula Bartáková Katarína Chalásová Lukáš Pácal Veronika Ťápalová Jan Máchal Petr Janků Kateřina Kaňková |
| author_facet | Vendula Bartáková Katarína Chalásová Lukáš Pácal Veronika Ťápalová Jan Máchal Petr Janků Kateřina Kaňková |
| author_sort | Vendula Bartáková |
| collection | DOAJ |
| description | <b>Background</b>: Women with gestational diabetes (GDM) have an increased risk of metabolic syndrome (MS) after delivery. MS could precede gravidity. The aims of this study were (i) to detect the prevalence of MS in women at the time of GDM diagnosis, (ii) to detect the prevalence of MS in the subgroup of GDM patients with any form of impaired glucose tolerance after delivery (PGI), and (iii) to determine whether GDM women with MS have a higher risk of peripartal adverse outcomes. <b>Methods</b><i>:</i> A cross-sectional observational study comprised <i>n</i> = 455 women with GDM. International Diabetes Federation (IDF) criteria for MS definition were modified to the pregnancy situation. <b>Results</b><i>:</i> MS was detected in 22.6% of GDM patients in those with PGI 40%. The presence of MS in GDM patients was associated with two peripartal outcomes: higher incidence of pathologic Apgar score and macrosomia (<i>p</i> = 0.01 resp. <i>p</i> = 0.0004, chi-square). <b>Conclusions</b><i>:</i> The presence of MS in GDM patients is a statistically significant risk factor (<i>p</i> = 0.04 chi-square) for PGI. A strong clinical implication of our findings might be to include MS diagnostics within GDM screening using modified MS criteria in the second trimester of pregnancy. |
| first_indexed | 2024-04-25T00:26:43Z |
| format | Article |
| id | doaj.art-86e6801d419a447a941603e96bdb6509 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:43Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-86e6801d419a447a941603e96bdb65092024-03-12T16:47:45ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135126010.3390/jcm13051260Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of GravidityVendula Bartáková0Katarína Chalásová1Lukáš Pácal2Veronika Ťápalová3Jan Máchal4Petr Janků5Kateřina Kaňková6Department of Pathophysiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech RepublicDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech RepublicDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech RepublicDepartment of Obstetrics and Gynaecology, University Hospital Brno, 66263 Brno, Czech RepublicDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech RepublicDepartment of Obstetrics and Gynaecology, University Hospital Brno, 66263 Brno, Czech RepublicDepartment of Pathophysiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic<b>Background</b>: Women with gestational diabetes (GDM) have an increased risk of metabolic syndrome (MS) after delivery. MS could precede gravidity. The aims of this study were (i) to detect the prevalence of MS in women at the time of GDM diagnosis, (ii) to detect the prevalence of MS in the subgroup of GDM patients with any form of impaired glucose tolerance after delivery (PGI), and (iii) to determine whether GDM women with MS have a higher risk of peripartal adverse outcomes. <b>Methods</b><i>:</i> A cross-sectional observational study comprised <i>n</i> = 455 women with GDM. International Diabetes Federation (IDF) criteria for MS definition were modified to the pregnancy situation. <b>Results</b><i>:</i> MS was detected in 22.6% of GDM patients in those with PGI 40%. The presence of MS in GDM patients was associated with two peripartal outcomes: higher incidence of pathologic Apgar score and macrosomia (<i>p</i> = 0.01 resp. <i>p</i> = 0.0004, chi-square). <b>Conclusions</b><i>:</i> The presence of MS in GDM patients is a statistically significant risk factor (<i>p</i> = 0.04 chi-square) for PGI. A strong clinical implication of our findings might be to include MS diagnostics within GDM screening using modified MS criteria in the second trimester of pregnancy.https://www.mdpi.com/2077-0383/13/5/1260gestational diabetes mellitusmetabolic syndromeoral glucose tolerance testpostpartum glucose intolerancepregnancy |
| spellingShingle | Vendula Bartáková Katarína Chalásová Lukáš Pácal Veronika Ťápalová Jan Máchal Petr Janků Kateřina Kaňková Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity Journal of Clinical Medicine gestational diabetes mellitus metabolic syndrome oral glucose tolerance test postpartum glucose intolerance pregnancy |
| title | Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity |
| title_full | Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity |
| title_fullStr | Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity |
| title_full_unstemmed | Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity |
| title_short | Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity |
| title_sort | metabolic syndrome prevalence in women with gestational diabetes mellitus in the second trimester of gravidity |
| topic | gestational diabetes mellitus metabolic syndrome oral glucose tolerance test postpartum glucose intolerance pregnancy |
| url | https://www.mdpi.com/2077-0383/13/5/1260 |
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