Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials.
<h4>Background</h4>Microbiome-directed therapies are increasingly utilized to optimize thyroid function in both healthy individuals and those with thyroid disorders. However, recent doubts have been raised regarding the efficacy of probiotics, prebiotics, and synbiotics in improving thyr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296733&type=printable |
| _version_ | 1797202052743430144 |
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| author | Qinxi Shu Chao Kang Jiaxin Li Zhenzhu Hou Minfen Xiong Xingang Wang Hongyan Peng |
| author_facet | Qinxi Shu Chao Kang Jiaxin Li Zhenzhu Hou Minfen Xiong Xingang Wang Hongyan Peng |
| author_sort | Qinxi Shu |
| collection | DOAJ |
| description | <h4>Background</h4>Microbiome-directed therapies are increasingly utilized to optimize thyroid function in both healthy individuals and those with thyroid disorders. However, recent doubts have been raised regarding the efficacy of probiotics, prebiotics, and synbiotics in improving thyroid function. This systematic review aimed to investigate the potential relationship between probiotics/prebiotics and thyroid function by analyzing the impact on thyroid hormone levels.<h4>Methods</h4>We conducted a comprehensive systematic review and meta-analysis of randomized controlled trials that investigated the effects of probiotics, prebiotics, and synbiotics on free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and thyroid stimulating hormone receptor antibody (TRAb) levels. We searched for articles from PubMed, Scopus, Web of Science, and Embase up until April 1st, 2023, without any language restriction. Quantitative data analysis was performed using a random-effects model, with standardized mean difference (SMD) and 95% confidence interval as summary statistics. The methods and results were reported according to the PRISMA2020 statement.<h4>Results</h4>A total of eight articles were included in this review. The meta-analysis showed no significant alterations in TSH (SMD: -0.01, 95% CI: -0.21, 0.20, P = 0.93; I2: 0.00%), fT4 (SMD: 0.04, 95% CI: -0.29, 0.21, P = 0.73; I2: 0.00%) or fT3 (SMD: 0.45, 95% CI: -0.14, 1.03, P = 0.43; I2: 78.00%), while a significant reduction in TRAb levels was observed (SMD: -0.85, 95% CI: -1.54, -0.15, P = 0.02; I2: 18.00%) following probiotics/prebiotics supplementation. No indication of publication bias was found.<h4>Conclusions</h4>Probiotics/prebiotics supplementation does not influence thyroid hormone levels, but may modestly reduce TRAb levels in patients with Graves' disease. |
| first_indexed | 2024-03-08T13:16:28Z |
| format | Article |
| id | doaj.art-86e6e5e79e574ae9846270310e91937c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T07:57:19Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-86e6e5e79e574ae9846270310e91937c2024-04-18T05:31:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01191e029673310.1371/journal.pone.0296733Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials.Qinxi ShuChao KangJiaxin LiZhenzhu HouMinfen XiongXingang WangHongyan Peng<h4>Background</h4>Microbiome-directed therapies are increasingly utilized to optimize thyroid function in both healthy individuals and those with thyroid disorders. However, recent doubts have been raised regarding the efficacy of probiotics, prebiotics, and synbiotics in improving thyroid function. This systematic review aimed to investigate the potential relationship between probiotics/prebiotics and thyroid function by analyzing the impact on thyroid hormone levels.<h4>Methods</h4>We conducted a comprehensive systematic review and meta-analysis of randomized controlled trials that investigated the effects of probiotics, prebiotics, and synbiotics on free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and thyroid stimulating hormone receptor antibody (TRAb) levels. We searched for articles from PubMed, Scopus, Web of Science, and Embase up until April 1st, 2023, without any language restriction. Quantitative data analysis was performed using a random-effects model, with standardized mean difference (SMD) and 95% confidence interval as summary statistics. The methods and results were reported according to the PRISMA2020 statement.<h4>Results</h4>A total of eight articles were included in this review. The meta-analysis showed no significant alterations in TSH (SMD: -0.01, 95% CI: -0.21, 0.20, P = 0.93; I2: 0.00%), fT4 (SMD: 0.04, 95% CI: -0.29, 0.21, P = 0.73; I2: 0.00%) or fT3 (SMD: 0.45, 95% CI: -0.14, 1.03, P = 0.43; I2: 78.00%), while a significant reduction in TRAb levels was observed (SMD: -0.85, 95% CI: -1.54, -0.15, P = 0.02; I2: 18.00%) following probiotics/prebiotics supplementation. No indication of publication bias was found.<h4>Conclusions</h4>Probiotics/prebiotics supplementation does not influence thyroid hormone levels, but may modestly reduce TRAb levels in patients with Graves' disease.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296733&type=printable |
| spellingShingle | Qinxi Shu Chao Kang Jiaxin Li Zhenzhu Hou Minfen Xiong Xingang Wang Hongyan Peng Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. PLoS ONE |
| title | Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. |
| title_full | Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. |
| title_fullStr | Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. |
| title_full_unstemmed | Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. |
| title_short | Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. |
| title_sort | effect of probiotics or prebiotics on thyroid function a meta analysis of eight randomized controlled trials |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296733&type=printable |
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