Use of Melatonin in Oxidative Stress Related Neonatal Diseases
Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish antioxidant defense. The peculi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/6/477 |
| _version_ | 1797566304588136448 |
|---|---|
| author | Gabriella D’Angelo Roberto Chimenz Russel J. Reiter Eloisa Gitto |
| author_facet | Gabriella D’Angelo Roberto Chimenz Russel J. Reiter Eloisa Gitto |
| author_sort | Gabriella D’Angelo |
| collection | DOAJ |
| description | Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish antioxidant defense. The peculiar susceptibility of newborns to oxidative stress supports the prophylactic use of melatonin in preventing or decreasing oxidative stress-mediated diseases. Melatonin, an effective direct free-radical scavenger, easily diffuses through biological membranes and exerts pleiotropic activity everywhere. Multiple investigations have assessed the effectiveness of melatonin to reduce the “oxygen radical diseases of newborn” including perinatal brain injury, sepsis, chronic lung disease (CLD), and necrotizing enterocolitis (NEC). Further studies are still awaited to test melatonin activity during perinatal period. |
| first_indexed | 2024-03-10T19:25:28Z |
| format | Article |
| id | doaj.art-86e86cecc39d4bc6b70bb5aa4186f7c4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T19:25:28Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-86e86cecc39d4bc6b70bb5aa4186f7c42023-11-20T02:36:44ZengMDPI AGAntioxidants2076-39212020-06-019647710.3390/antiox9060477Use of Melatonin in Oxidative Stress Related Neonatal DiseasesGabriella D’Angelo0Roberto Chimenz1Russel J. Reiter2Eloisa Gitto3Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyUnit of Pediatric Nephrology and Rheumatology with Dialysis, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyDepartment of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 40729, USANeonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyReactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish antioxidant defense. The peculiar susceptibility of newborns to oxidative stress supports the prophylactic use of melatonin in preventing or decreasing oxidative stress-mediated diseases. Melatonin, an effective direct free-radical scavenger, easily diffuses through biological membranes and exerts pleiotropic activity everywhere. Multiple investigations have assessed the effectiveness of melatonin to reduce the “oxygen radical diseases of newborn” including perinatal brain injury, sepsis, chronic lung disease (CLD), and necrotizing enterocolitis (NEC). Further studies are still awaited to test melatonin activity during perinatal period.https://www.mdpi.com/2076-3921/9/6/477oxidative stresspreterm newborninfantmelatonin |
| spellingShingle | Gabriella D’Angelo Roberto Chimenz Russel J. Reiter Eloisa Gitto Use of Melatonin in Oxidative Stress Related Neonatal Diseases Antioxidants oxidative stress preterm newborn infant melatonin |
| title | Use of Melatonin in Oxidative Stress Related Neonatal Diseases |
| title_full | Use of Melatonin in Oxidative Stress Related Neonatal Diseases |
| title_fullStr | Use of Melatonin in Oxidative Stress Related Neonatal Diseases |
| title_full_unstemmed | Use of Melatonin in Oxidative Stress Related Neonatal Diseases |
| title_short | Use of Melatonin in Oxidative Stress Related Neonatal Diseases |
| title_sort | use of melatonin in oxidative stress related neonatal diseases |
| topic | oxidative stress preterm newborn infant melatonin |
| url | https://www.mdpi.com/2076-3921/9/6/477 |
| work_keys_str_mv | AT gabrielladangelo useofmelatonininoxidativestressrelatedneonataldiseases AT robertochimenz useofmelatonininoxidativestressrelatedneonataldiseases AT russeljreiter useofmelatonininoxidativestressrelatedneonataldiseases AT eloisagitto useofmelatonininoxidativestressrelatedneonataldiseases |