Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice
Abstract Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles of sweet sensing by a T1R3-dependent taste receptor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Physiological Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12576-023-00875-3 |
| _version_ | 1827875608769593344 |
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| author | Mitsuhito Takamori Yoshihiro Mitoh Kengo Horie Masahiko Egusa Takuya Miyawaki Ryusuke Yoshida |
| author_facet | Mitsuhito Takamori Yoshihiro Mitoh Kengo Horie Masahiko Egusa Takuya Miyawaki Ryusuke Yoshida |
| author_sort | Mitsuhito Takamori |
| collection | DOAJ |
| description | Abstract Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles of sweet sensing by a T1R3-dependent taste receptor and sugar sensing by oral glucose transporters in the oropharyngeal region in inducing CPIR. Spontaneous oral ingestion of glucose significantly increased plasma insulin 5 min later in wild-type (C57BL/6) and T1R3-knockout mice, but intragastric infusion did not. Oral treatment of glucose transporter inhibitors phlorizin and phloretin significantly reduced CPIR after spontaneous oral ingestion. In addition, a rapid increase in plasma insulin was significantly smaller in WT mice with spontaneous oral ingestion of nonmetabolizable glucose analog than in WT mice with spontaneous oral ingestion of glucose. Taken together, the T1R3-dependent receptor is not required for CPIR, but oral glucose transporters greatly contribute to induction of CPIR by sugars. |
| first_indexed | 2024-03-12T17:09:21Z |
| format | Article |
| id | doaj.art-86e8bd7803a24548939d46390b08d27b |
| institution | Directory Open Access Journal |
| issn | 1880-6562 |
| language | English |
| last_indexed | 2024-03-12T17:09:21Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj.art-86e8bd7803a24548939d46390b08d27b2023-08-06T11:09:12ZengBMCJournal of Physiological Sciences1880-65622023-07-0173111110.1186/s12576-023-00875-3Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in miceMitsuhito Takamori0Yoshihiro Mitoh1Kengo Horie2Masahiko Egusa3Takuya Miyawaki4Ryusuke Yoshida5Department of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityDepartment of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityDepartment of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityThe Center for Special Needs Dentistry, Okayama University HospitalDepartment of Dental Anesthesiology and Special Care Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityDepartment of Oral Physiology, Graduate School of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityAbstract Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles of sweet sensing by a T1R3-dependent taste receptor and sugar sensing by oral glucose transporters in the oropharyngeal region in inducing CPIR. Spontaneous oral ingestion of glucose significantly increased plasma insulin 5 min later in wild-type (C57BL/6) and T1R3-knockout mice, but intragastric infusion did not. Oral treatment of glucose transporter inhibitors phlorizin and phloretin significantly reduced CPIR after spontaneous oral ingestion. In addition, a rapid increase in plasma insulin was significantly smaller in WT mice with spontaneous oral ingestion of nonmetabolizable glucose analog than in WT mice with spontaneous oral ingestion of glucose. Taken together, the T1R3-dependent receptor is not required for CPIR, but oral glucose transporters greatly contribute to induction of CPIR by sugars.https://doi.org/10.1186/s12576-023-00875-3Cephalic-phase insulin responseGlucose transportersGlucoseSweet taste receptorFood intake |
| spellingShingle | Mitsuhito Takamori Yoshihiro Mitoh Kengo Horie Masahiko Egusa Takuya Miyawaki Ryusuke Yoshida Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice Journal of Physiological Sciences Cephalic-phase insulin response Glucose transporters Glucose Sweet taste receptor Food intake |
| title | Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice |
| title_full | Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice |
| title_fullStr | Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice |
| title_full_unstemmed | Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice |
| title_short | Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice |
| title_sort | sugar signals from oral glucose transporters elicit cephalic phase insulin release in mice |
| topic | Cephalic-phase insulin response Glucose transporters Glucose Sweet taste receptor Food intake |
| url | https://doi.org/10.1186/s12576-023-00875-3 |
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