Zinc in the Brain: Friend or Foe?
Zinc is a trace metal ion in the central nervous system that plays important biological roles, such as in catalysis, structure, and regulation. It contributes to antioxidant function and the proper functioning of the immune system. In view of these characteristics of zinc, it plays an important role...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/23/8941 |
| _version_ | 1797546852455809024 |
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| author | Seunghyuk Choi Dae Ki Hong Bo Young Choi Sang Won Suh |
| author_facet | Seunghyuk Choi Dae Ki Hong Bo Young Choi Sang Won Suh |
| author_sort | Seunghyuk Choi |
| collection | DOAJ |
| description | Zinc is a trace metal ion in the central nervous system that plays important biological roles, such as in catalysis, structure, and regulation. It contributes to antioxidant function and the proper functioning of the immune system. In view of these characteristics of zinc, it plays an important role in neurophysiology, which leads to cell growth and cell proliferation. However, after brain disease, excessively released and accumulated zinc ions cause neurotoxic damage to postsynaptic neurons. On the other hand, zinc deficiency induces degeneration and cognitive decline disorders, such as increased neuronal death and decreased learning and memory. Given the importance of balance in this context, zinc is a biological component that plays an important physiological role in the central nervous system, but a pathophysiological role in major neurological disorders. In this review, we focus on the multiple roles of zinc in the brain. |
| first_indexed | 2024-03-10T14:35:06Z |
| format | Article |
| id | doaj.art-86e9ab5e13ff4d8c8327074a11129c9b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:35:06Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-86e9ab5e13ff4d8c8327074a11129c9b2023-11-20T22:16:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012123894110.3390/ijms21238941Zinc in the Brain: Friend or Foe?Seunghyuk Choi0Dae Ki Hong1Bo Young Choi2Sang Won Suh3Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaZinc is a trace metal ion in the central nervous system that plays important biological roles, such as in catalysis, structure, and regulation. It contributes to antioxidant function and the proper functioning of the immune system. In view of these characteristics of zinc, it plays an important role in neurophysiology, which leads to cell growth and cell proliferation. However, after brain disease, excessively released and accumulated zinc ions cause neurotoxic damage to postsynaptic neurons. On the other hand, zinc deficiency induces degeneration and cognitive decline disorders, such as increased neuronal death and decreased learning and memory. Given the importance of balance in this context, zinc is a biological component that plays an important physiological role in the central nervous system, but a pathophysiological role in major neurological disorders. In this review, we focus on the multiple roles of zinc in the brain.https://www.mdpi.com/1422-0067/21/23/8941zincphysiologypathophysiologybrain |
| spellingShingle | Seunghyuk Choi Dae Ki Hong Bo Young Choi Sang Won Suh Zinc in the Brain: Friend or Foe? International Journal of Molecular Sciences zinc physiology pathophysiology brain |
| title | Zinc in the Brain: Friend or Foe? |
| title_full | Zinc in the Brain: Friend or Foe? |
| title_fullStr | Zinc in the Brain: Friend or Foe? |
| title_full_unstemmed | Zinc in the Brain: Friend or Foe? |
| title_short | Zinc in the Brain: Friend or Foe? |
| title_sort | zinc in the brain friend or foe |
| topic | zinc physiology pathophysiology brain |
| url | https://www.mdpi.com/1422-0067/21/23/8941 |
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