A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis
Obesity has become a global public health and economic problem. Obesity is a major risk factor for a number of complications, such as type 2 diabetes, cardiovascular disease, fatty liver disease, and cancer. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic monoamine that plays various roles in m...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/5/2452 |
| _version_ | 1797416876327829504 |
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| author | Suhyeon Park Yumin Kim Jibeom Lee Jeong Yun Lee Hail Kim Sunjae Lee Chang-Myung Oh |
| author_facet | Suhyeon Park Yumin Kim Jibeom Lee Jeong Yun Lee Hail Kim Sunjae Lee Chang-Myung Oh |
| author_sort | Suhyeon Park |
| collection | DOAJ |
| description | Obesity has become a global public health and economic problem. Obesity is a major risk factor for a number of complications, such as type 2 diabetes, cardiovascular disease, fatty liver disease, and cancer. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic monoamine that plays various roles in metabolic homeostasis. It is well known that central 5-HT regulates appetite and mood. Several 5-HT receptor agonists and selective serotonin receptor uptake inhibitors (SSRIs) have shown beneficial effects on appetite and mood control in clinics. Although several genetic polymorphisms related to 5-HT synthesis and its receptors are strongly associated with obesity, there is little evidence of the role of peripheral 5-HT in human metabolism. In this study, we performed a systemic analysis of transcriptome data from the Genotype-Tissue Expression (GTEX) database. We investigated the expression of 5-HT and tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT biosynthesis, in the human brain and peripheral tissues. We also performed differential gene expression analysis and predicted changes in metabolites by comparing gene expressions of tissues with high TPH expression to the gene expressions of tissues with low TPH expression. Our analyses provide strong evidence that serotonin plays an important role in the regulation of metabolic homeostasis in humans. |
| first_indexed | 2024-03-09T06:10:32Z |
| format | Article |
| id | doaj.art-86ebb49ad6bc4914812a5bf4ebd252a0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T06:10:32Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-86ebb49ad6bc4914812a5bf4ebd252a02023-12-03T11:59:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01225245210.3390/ijms22052452A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic HomeostasisSuhyeon Park0Yumin Kim1Jibeom Lee2Jeong Yun Lee3Hail Kim4Sunjae Lee5Chang-Myung Oh6Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, KoreaDepartment of School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaObesity has become a global public health and economic problem. Obesity is a major risk factor for a number of complications, such as type 2 diabetes, cardiovascular disease, fatty liver disease, and cancer. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic monoamine that plays various roles in metabolic homeostasis. It is well known that central 5-HT regulates appetite and mood. Several 5-HT receptor agonists and selective serotonin receptor uptake inhibitors (SSRIs) have shown beneficial effects on appetite and mood control in clinics. Although several genetic polymorphisms related to 5-HT synthesis and its receptors are strongly associated with obesity, there is little evidence of the role of peripheral 5-HT in human metabolism. In this study, we performed a systemic analysis of transcriptome data from the Genotype-Tissue Expression (GTEX) database. We investigated the expression of 5-HT and tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT biosynthesis, in the human brain and peripheral tissues. We also performed differential gene expression analysis and predicted changes in metabolites by comparing gene expressions of tissues with high TPH expression to the gene expressions of tissues with low TPH expression. Our analyses provide strong evidence that serotonin plays an important role in the regulation of metabolic homeostasis in humans.https://www.mdpi.com/1422-0067/22/5/2452serotoninmetabolic homeostasissystems biology |
| spellingShingle | Suhyeon Park Yumin Kim Jibeom Lee Jeong Yun Lee Hail Kim Sunjae Lee Chang-Myung Oh A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis International Journal of Molecular Sciences serotonin metabolic homeostasis systems biology |
| title | A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis |
| title_full | A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis |
| title_fullStr | A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis |
| title_full_unstemmed | A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis |
| title_short | A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis |
| title_sort | systems biology approach to investigating the interaction between serotonin synthesis by tryptophan hydroxylase and the metabolic homeostasis |
| topic | serotonin metabolic homeostasis systems biology |
| url | https://www.mdpi.com/1422-0067/22/5/2452 |
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