Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects
Fibrosis, a disease characterized by an excess accumulation of extracellular matrix components, could lead to organ failure and death, and is to blame for up to 45 % of all fatalities in developed nations. These disorders all share the common trait of an unchecked and increasing accumulation of fibr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222013671 |
| _version_ | 1811300263721435136 |
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| author | Xun Ye Jinhu Li Zibo Liu Xue Sun Daneng Wei Linjiang Song Chunjie Wu |
| author_facet | Xun Ye Jinhu Li Zibo Liu Xue Sun Daneng Wei Linjiang Song Chunjie Wu |
| author_sort | Xun Ye |
| collection | DOAJ |
| description | Fibrosis, a disease characterized by an excess accumulation of extracellular matrix components, could lead to organ failure and death, and is to blame for up to 45 % of all fatalities in developed nations. These disorders all share the common trait of an unchecked and increasing accumulation of fibrotic tissue in the affected organs, which leads to their malfunction and eventual failure, even if their underlying causes are highly diverse and, in some cases, remain unclear. Numerous studies have identified activated myofibroblasts as the common cellular elements ultimately responsible for the replacement of normal tissues with nonfunctional fibrotic tissue. The transforming growth factor-β pathway, for instance, plays a significant role in practically all kinds of fibrosis. However, there is no specific drug for the treatment of fibrosis, several medications with anti-hepatic fibrosis properties are still in the research and development stages. Peptide, which refers to a substance consisting of 2–50 amino acids, is characterized by structural diversity, low toxicity, biological activities, easy absorption, specific targeting, few side effects, and has been proven to be effective in anti-fibrosis. Here, we summarized various anti-fibrosis peptides in fibrosis including the liver, lungs, kidneys, and other organs. This review will provide a new insight into peptide mediated anti-fibrosis and is helpful to creation of antifibrotic medications. |
| first_indexed | 2024-04-13T06:48:29Z |
| format | Article |
| id | doaj.art-86ec24019b6a425581a882643d92873a |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T06:48:29Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-86ec24019b6a425581a882643d92873a2022-12-22T02:57:28ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157113978Peptide mediated therapy in fibrosis: Mechanisms, advances and prospectsXun Ye0Jinhu Li1Zibo Liu2Xue Sun3Daneng Wei4Linjiang Song5Chunjie Wu6School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China; Corresponding author.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China; Correspondence to: School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.Fibrosis, a disease characterized by an excess accumulation of extracellular matrix components, could lead to organ failure and death, and is to blame for up to 45 % of all fatalities in developed nations. These disorders all share the common trait of an unchecked and increasing accumulation of fibrotic tissue in the affected organs, which leads to their malfunction and eventual failure, even if their underlying causes are highly diverse and, in some cases, remain unclear. Numerous studies have identified activated myofibroblasts as the common cellular elements ultimately responsible for the replacement of normal tissues with nonfunctional fibrotic tissue. The transforming growth factor-β pathway, for instance, plays a significant role in practically all kinds of fibrosis. However, there is no specific drug for the treatment of fibrosis, several medications with anti-hepatic fibrosis properties are still in the research and development stages. Peptide, which refers to a substance consisting of 2–50 amino acids, is characterized by structural diversity, low toxicity, biological activities, easy absorption, specific targeting, few side effects, and has been proven to be effective in anti-fibrosis. Here, we summarized various anti-fibrosis peptides in fibrosis including the liver, lungs, kidneys, and other organs. This review will provide a new insight into peptide mediated anti-fibrosis and is helpful to creation of antifibrotic medications.http://www.sciencedirect.com/science/article/pii/S0753332222013671FibrosisPeptideInflammationTGF-βExtracellular matrix components |
| spellingShingle | Xun Ye Jinhu Li Zibo Liu Xue Sun Daneng Wei Linjiang Song Chunjie Wu Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects Biomedicine & Pharmacotherapy Fibrosis Peptide Inflammation TGF-β Extracellular matrix components |
| title | Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects |
| title_full | Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects |
| title_fullStr | Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects |
| title_full_unstemmed | Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects |
| title_short | Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects |
| title_sort | peptide mediated therapy in fibrosis mechanisms advances and prospects |
| topic | Fibrosis Peptide Inflammation TGF-β Extracellular matrix components |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222013671 |
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