Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study.
Current methods of measuring the population burden of injuries rely on many assumptions and limited data available to the global burden of diseases (GBD) studies. The aim of this study was to compare the population burden of injuries using different approaches from the UK Burden of Injury (UKBOI) an...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-12-01
|
| Series: | PLoS Medicine |
| Online Access: | http://europepmc.org/articles/PMC3232198?pdf=render |
| _version_ | 1811197608752840704 |
|---|---|
| author | Ronan A Lyons Denise Kendrick Elizabeth M Towner Nicola Christie Steven Macey Carol Coupland Belinda J Gabbe UK Burden of Injuries Study Group |
| author_facet | Ronan A Lyons Denise Kendrick Elizabeth M Towner Nicola Christie Steven Macey Carol Coupland Belinda J Gabbe UK Burden of Injuries Study Group |
| author_sort | Ronan A Lyons |
| collection | DOAJ |
| description | Current methods of measuring the population burden of injuries rely on many assumptions and limited data available to the global burden of diseases (GBD) studies. The aim of this study was to compare the population burden of injuries using different approaches from the UK Burden of Injury (UKBOI) and GBD studies.The UKBOI was a prospective cohort of 1,517 injured individuals that collected patient-reported outcomes. Extrapolated outcome data were combined with multiple sources of morbidity and mortality data to derive population metrics of the burden of injury in the UK. Participants were injured patients recruited from hospitals in four UK cities and towns: Swansea, Nottingham, Bristol, and Guildford, between September 2005 and April 2007. Patient-reported changes in quality of life using the EQ-5D at baseline, 1, 4, and 12 months after injury provided disability weights used to calculate the years lived with disability (YLDs) component of disability adjusted life years (DALYs). DALYs were calculated for the UK and extrapolated to global estimates using both UKBOI and GBD disability weights. Estimated numbers (and rates per 100,000) for UK population extrapolations were 750,999 (1,240) for hospital admissions, 7,982,947 (13,339) for emergency department (ED) attendances, and 22,185 (36.8) for injury-related deaths in 2005. Nonadmitted ED-treated injuries accounted for 67% of YLDs. Estimates for UK DALYs amounted to 1,771,486 (82% due to YLDs), compared with 669,822 (52% due to YLDs) using the GBD approach. Extrapolating patient-derived disability weights to GBD estimates would increase injury-related DALYs 2.6-fold.The use of disability weights derived from patient experiences combined with additional morbidity data on ED-treated patients and inpatients suggests that the absolute burden of injury is higher than previously estimated. These findings have substantial implications for improving measurement of the national and global burden of injury. |
| first_indexed | 2024-04-12T01:16:36Z |
| format | Article |
| id | doaj.art-86ee4905466c4c469388437b3a96a9d1 |
| institution | Directory Open Access Journal |
| issn | 1549-1277 1549-1676 |
| language | English |
| last_indexed | 2024-04-12T01:16:36Z |
| publishDate | 2011-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj.art-86ee4905466c4c469388437b3a96a9d12022-12-22T03:53:55ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762011-12-01812e100114010.1371/journal.pmed.1001140Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study.Ronan A LyonsDenise KendrickElizabeth M TownerNicola ChristieSteven MaceyCarol CouplandBelinda J GabbeUK Burden of Injuries Study GroupCurrent methods of measuring the population burden of injuries rely on many assumptions and limited data available to the global burden of diseases (GBD) studies. The aim of this study was to compare the population burden of injuries using different approaches from the UK Burden of Injury (UKBOI) and GBD studies.The UKBOI was a prospective cohort of 1,517 injured individuals that collected patient-reported outcomes. Extrapolated outcome data were combined with multiple sources of morbidity and mortality data to derive population metrics of the burden of injury in the UK. Participants were injured patients recruited from hospitals in four UK cities and towns: Swansea, Nottingham, Bristol, and Guildford, between September 2005 and April 2007. Patient-reported changes in quality of life using the EQ-5D at baseline, 1, 4, and 12 months after injury provided disability weights used to calculate the years lived with disability (YLDs) component of disability adjusted life years (DALYs). DALYs were calculated for the UK and extrapolated to global estimates using both UKBOI and GBD disability weights. Estimated numbers (and rates per 100,000) for UK population extrapolations were 750,999 (1,240) for hospital admissions, 7,982,947 (13,339) for emergency department (ED) attendances, and 22,185 (36.8) for injury-related deaths in 2005. Nonadmitted ED-treated injuries accounted for 67% of YLDs. Estimates for UK DALYs amounted to 1,771,486 (82% due to YLDs), compared with 669,822 (52% due to YLDs) using the GBD approach. Extrapolating patient-derived disability weights to GBD estimates would increase injury-related DALYs 2.6-fold.The use of disability weights derived from patient experiences combined with additional morbidity data on ED-treated patients and inpatients suggests that the absolute burden of injury is higher than previously estimated. These findings have substantial implications for improving measurement of the national and global burden of injury.http://europepmc.org/articles/PMC3232198?pdf=render |
| spellingShingle | Ronan A Lyons Denise Kendrick Elizabeth M Towner Nicola Christie Steven Macey Carol Coupland Belinda J Gabbe UK Burden of Injuries Study Group Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study. PLoS Medicine |
| title | Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study. |
| title_full | Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study. |
| title_fullStr | Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study. |
| title_full_unstemmed | Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study. |
| title_short | Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study. |
| title_sort | measuring the population burden of injuries implications for global and national estimates a multi centre prospective uk longitudinal study |
| url | http://europepmc.org/articles/PMC3232198?pdf=render |
| work_keys_str_mv | AT ronanalyons measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT denisekendrick measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT elizabethmtowner measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT nicolachristie measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT stevenmacey measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT carolcoupland measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT belindajgabbe measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy AT ukburdenofinjuriesstudygroup measuringthepopulationburdenofinjuriesimplicationsforglobalandnationalestimatesamulticentreprospectiveuklongitudinalstudy |