Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/11/1886 |
| _version_ | 1797508805493260288 |
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| author | Michele D. M. Lombardo Laura Mangiavini Giuseppe M. Peretti |
| author_facet | Michele D. M. Lombardo Laura Mangiavini Giuseppe M. Peretti |
| author_sort | Michele D. M. Lombardo |
| collection | DOAJ |
| description | Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injuries |
| first_indexed | 2024-03-10T05:09:06Z |
| format | Article |
| id | doaj.art-86f1e2d7fe494e6ca34df61b9f9f64fe |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:09:06Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-86f1e2d7fe494e6ca34df61b9f9f64fe2023-11-23T00:59:08ZengMDPI AGPharmaceutics1999-49232021-11-011311188610.3390/pharmaceutics13111886Biomaterials and Meniscal Lesions: Current Concepts and Future PerspectiveMichele D. M. Lombardo0Laura Mangiavini1Giuseppe M. Peretti2Residency Program in Orthopedics and Traumatology, University of Milan, 20122 Milan, ItalyIRCCS Istituto Ortopedico Galeazzi, 20100 Milan, ItalyIRCCS Istituto Ortopedico Galeazzi, 20100 Milan, ItalyMenisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injurieshttps://www.mdpi.com/1999-4923/13/11/1886meniscusbiomaterialscaffoldpolymerbioprintingstem cells |
| spellingShingle | Michele D. M. Lombardo Laura Mangiavini Giuseppe M. Peretti Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective Pharmaceutics meniscus biomaterial scaffold polymer bioprinting stem cells |
| title | Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective |
| title_full | Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective |
| title_fullStr | Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective |
| title_full_unstemmed | Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective |
| title_short | Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective |
| title_sort | biomaterials and meniscal lesions current concepts and future perspective |
| topic | meniscus biomaterial scaffold polymer bioprinting stem cells |
| url | https://www.mdpi.com/1999-4923/13/11/1886 |
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