Numerical analysis of etoposide induced DNA breaks.

Numerical analysis of etoposide induced DNA breaks.

BACKGROUND:Etoposide is a cancer drug that induces strand breaks in cellular DNA by inhibiting topoisomerase II (topoII) religation of cleaved DNA molecules. Although DNA cleavage by topoisomerase II always produces topoisomerase II-linked DNA double-strand breaks (DSBs), the action of etoposide als...

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Bibliographic Details
Main Authors: Aida Muslimović, Susanne Nyström, Yue Gao, Ola Hammarsten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2689654?pdf=render

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