Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures
This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of de...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023046108 |
| _version_ | 1827918514458984448 |
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| author | Homa Rezaei Elaheh Rahimpour Fleming Martinez Abolghasem Jouyban |
| author_facet | Homa Rezaei Elaheh Rahimpour Fleming Martinez Abolghasem Jouyban |
| author_sort | Homa Rezaei |
| collection | DOAJ |
| description | This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with both temperature and propylene glycol mass fraction. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the low mean relative deviation values of less than 3.6% illustrate the good agreement of computed data with the experimental data. The apparent thermodynamic behavior of deferiprone dissolution was also investigated according to van’t Hoff and Gibbs equation. |
| first_indexed | 2024-03-13T03:44:43Z |
| format | Article |
| id | doaj.art-86f26a89f7f04fc49b11626ccf9d188b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T03:44:43Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-86f26a89f7f04fc49b11626ccf9d188b2023-06-23T04:43:20ZengElsevierHeliyon2405-84402023-06-0196e17402Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperaturesHoma Rezaei0Elaheh Rahimpour1Fleming Martinez2Abolghasem Jouyban3Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranPharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Universidad Nacional de Colombia, Sede Bogotá, Cra. 30 No. 45-03, Bogotá D. C., ColombiaPharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranThis investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with both temperature and propylene glycol mass fraction. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the low mean relative deviation values of less than 3.6% illustrate the good agreement of computed data with the experimental data. The apparent thermodynamic behavior of deferiprone dissolution was also investigated according to van’t Hoff and Gibbs equation.http://www.sciencedirect.com/science/article/pii/S2405844023046108solubilityDeferiproneBinary solvent mixturesCosolvency modelsThermodynamics |
| spellingShingle | Homa Rezaei Elaheh Rahimpour Fleming Martinez Abolghasem Jouyban Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures Heliyon solubility Deferiprone Binary solvent mixtures Cosolvency models Thermodynamics |
| title | Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures |
| title_full | Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures |
| title_fullStr | Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures |
| title_full_unstemmed | Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures |
| title_short | Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures |
| title_sort | measurement and correlation of solubility data for deferiprone in propylene glycol and 2 propanol at different temperatures |
| topic | solubility Deferiprone Binary solvent mixtures Cosolvency models Thermodynamics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023046108 |
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